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在晚期卵巢癌中高热性腹腔内化疗的有效性:一个书籍测量分析和更新的元分析

Jianbo Wei¹, Yangzhi Qiu², Ziang Ding²

¹Department of Gynaecology and Obstetrics, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, Guangdong, China; Guangdong Provincial Clinical Research Center for Obstetrics and Gynecology, Guangzhou, China.

European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology

|November 27, 2025

概括

超热性腹膜内化学疗法 (HIPEC) 改善了晚期卵巢癌患者的生存率. 该研究强调了它的益处,特别是在新辅助化疗后,并呼吁进行更多高质量的试验.

科学领域:

妇科瘤学妇科瘤学
手术瘤学手术瘤学
基于证据的医学基于证据的医学.

背景情况:

晚期卵巢癌是女性癌症死亡的主要原因之一.
在治疗晚期卵巢癌方面,高热性腹腔内化疗 (HIPEC) 的作用受到争议.
这项研究综合了高级别的证据,以澄清HIPEC的有效性.

研究的目的:

评估HIPEC在晚期卵巢癌中的临床有效性.
分析HIPEC在卵巢癌治疗中的研究趋势和前景.
整合随机对照试验 (RCT) 的发现,以得出可靠的结论.

主要方法:

到2025年6月,对RCT进行系统的文献搜索.
使用已知软件 (Review Manager,Bibliometrix,VOSviewer) 进行元分析和文献计量审查.
PICOS框架用于研究选择和整体存活率 (OS) 和无进展生存率 (PFS) 的分析.

主要成果:

分析了9个涉及1621名患者的RCT.
在初级和复发性卵巢癌中,HIPEC显著改善了OS.
在初级卵巢癌中,HIPEC改善了PFS,在新辅助化疗 (NACT) 和开放的HIPEC技术后有显著的好处.

结论:

对于晚期卵巢癌,HIPEC提供了积极的预后,特别是初级病例和接受NACT的患者.
该领域的研究活动越来越多,美国和中国的贡献很大.
建议进一步进行大规模,高质量的RCT,以加强对卵巢癌中HIPEC的证据.

关键词:

图书统计系统 (Bibliometric) 是一个图书统计系统.细胞还原性手术是指细胞还原性手术.头 - - 头是一个头.超热内皮管内化学疗法超热内皮管内化学疗法新辅助化学疗法新辅助化学疗法卵巢癌是发生在卵巢中的癌症.

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