欧米茄-3补充剂使用与韩国老年人认知功能之间的关联:一项为期8年的纵向队列研究
Won Man Lee1, So Im Ryu2, Myoung-Nam Lim3
1Department of Psychiatry, Kangwon National University Hospital, 156, Baengnyeong-ro, Chuncheon-si, Gangwon-do 24289, Republic of Korea.
The journal of nutrition, health & aging
|November 27, 2025
概括
欧米茄-3脂肪酸 (O3FA) 补充与八年来老年人认知表现的改善有关. 长期使用O3FA的用户表现出更大的认知效益,这表明O3FA在衰老期间在支持大脑健康方面发挥了作用.
科学领域:
- 老年学和认知神经科学
- 营养精神病学 营养精神病学
- 公共卫生与老龄化问题
背景情况:
- 韩国由于饮食习惯而表现出高基线omega-3脂肪酸 (O3FA) 摄入量.
- 在这个人群中,O3FA补充剂对额外的认知益处的研究有限.
- 了解O3FA的作用对于维持老年人的认知功能至关重要.
研究的目的:
- 研究O3FA补充剂对韩国老年人的认知表现的纵向影响.
- 检查O3FA补充剂的持续时间与8年内认知结果之间的关系.
主要方法:
- 潜在的纵向队列研究设计,利用韩国认知衰老和痴呆的纵向研究 (KLOSCAD) 的数据.
- 包括4949名60岁以上的成年人,其中2053人完成了8年的随访.
- 通过使用CERAD-K神经心理评估电池 (CERAD-K[N]) 通过问卷和认知功能评估O3FA补充剂的使用,使用反复测量ANCOVA和线性混合效应模型 (LMMs) 进行分析.
主要成果:
- 在为期8年的研究期间,O3FA用户在整体认知得分 (CERAD-K[N]) 和记忆域得分方面表现出显著的改善.
- 权重LMM分析显示了时间和补充时间之间的显著相互作用,表明长期使用O3FA与更大的认知改善有关.
- 这些发现突出了O3FA补充剂对认知维持的剂量-反应或持续时间依赖的影响.
结论:
- 欧米茄-3脂肪酸 (O3FA) 补充剂的使用与社区居住的老年人更好地维持认知功能有关.
- 这些发现表明,O3FA补充剂可能在支持整个衰老过程中的认知健康方面发挥有益作用.
- 对认知衰老的最佳O3FA摄入策略进行进一步的研究是有必要的.
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