在一个潜在的家庭传播研究中,比较SARS-CoV-2感染的定义
Jonas Frost1, Bianca Klee1, Sophie Diexer1
1Institute for Medical Epidemiology, Biometrics and Informatics, Interdisciplinary Centre for Health Sciences, Medical Faculty of the Martin Luther University Halle-Wittenberg, Magdeburger Str. 8, Halle (Saale) 06112, Germany.
检测SARS-CoV-2再感染需要超出简单血清转换的方法,特别是在高血清流行率的人群中. 显著的抗体位数增加可靠地识别感染,包括无症状病例和再感染.
科学领域:
- 流行病学 流行病学
- 免疫学 免疫学 免疫学
- 传染性疾病 传染性疾病
背景情况:
- 准确识别SARS-CoV-2感染,特别是无症状病例和再感染,在现场研究中存在挑战.
- 现有的感染和再感染检测定义可能不足,特别是在具有高先前感染率的人群中.
研究的目的:
- 为了比较SARS-CoV-2感染的不同定义.
- 建立一种可靠的血清学方法来检测基于抗体位数增加的再感染.
主要方法:
- 一项涉及德国数字队列DigiHero的389名参与者的家庭传播研究.
- 在6到8周内采集症状数据和两个血清样本 (S和N抗体),使用干血斑点卡.
- 使用各种基于文献的定义和两种再感染意识的血清学方法计算二次攻击率 (SARs).
主要成果:
- 根据所使用的定义,二次攻击率有很大差异.
- 当仅依靠血清转化时,高的初始血清流行率导致了超过20%的SAR低估.
- 基于症状的定义导致由于其他病原体和遗漏的无症状感染而导致错误分类.
结论:
- 仅仅通过血清转化就不足以在高血清流行率环境中检测感染.
- 基于症状的方法无法解释无症状的SARS-CoV-2感染.
- 在样本之间监测实质性抗体标位增加可靠地检测感染,包括无症状和再感染病例,并适用于其他病原体.
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