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淋巴细胞与单细胞的比率作为突发感神经听力损失的临床预测因素

Elvan Onan¹, Ozgur Surmelioglu¹, Caglar Eker¹

¹Çukurova University, Faculty of Medicine, Department of Otorhinolaryngology, Adana, Turkey.

Brazilian journal of otorhinolaryngology

|November 27, 2025

概括

系统性炎症标志物,如中性粒细胞与淋巴细胞的比率 (NLR),在突然的感觉神经听力损失 (SSNHL) 中升高. 低淋巴细胞与单细胞比率 (LMR) 独立预测SSNHL预后不佳.

科学领域:

耳鼻喉科耳鼻喉科耳鼻喉科
炎症研究的研究.
听力学听力学是指听力学.

背景情况:

突然感觉神经听力损失 (SSNHL) 是一种耳学紧急情况,预后可变.
系统性炎症标志物越来越多地被认为是它们在各种病理中的作用.
在SSNHL中特定炎症标志物的预后价值需要进一步阐明.

研究的目的:

评估中性粒细胞与淋巴细胞比率 (NLR),淋巴细胞与单细胞比率 (LMR),血小板与淋巴细胞比率 (PLR) 和系统性免疫炎症指数 (SII) 的预后意义.

主要方法:

对120名SSNHL患者和健康对照的回顾性分析.
收集人口统计数据,听力测量结果和常规血液参数.
在两个月后使用西格尔标准评估听力恢复.

主要成果:

与对照组相比,SSNHL患者表现出较高的NLR,PLR和SII.
在康复和未康复的SSNHL组之间发现了中性粒细胞计数,淋巴细胞计数,PDW,NLR,PLR,LMR和SII的显著差异.
通过逻辑回归 (R2=0.271),低LMR被确定为SSNHL预后不佳的独立预测因素.

结论:

升高的NLR,PLR和SII可能表明SSNHL的炎症过程和微血管功能障碍.
LMR是一种新且潜在的有价值的预后生物标志物,用于预测SSNHL治疗结果.
LMR的预测能力凸显了它在管理SSNHL患者中的重要性.

关键词:

炎症标志物是一种炎症标志物.淋巴细胞与单细胞的比率中性粒细胞与淋巴细胞的比率.血小板与淋巴细胞的比率.突然感觉神经听力损失 (SSNHL)

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