中性粒细胞与淋巴细胞的比率和心血管疾病或癌症的死亡率:基于人口的队列研究
Moustafa I Morsy1, Jocelyn M Friday2, Jill P Pell2
1School of Infection & Immunity, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, United Kingdom.
JACC. Advances
|November 27, 2025
概括
较高的中性粒细胞与淋巴细胞比率 (NLR) 表明心血管疾病 (CVD),心力衰竭 (HF) 或癌症的成年人死亡风险增加. 这一发现表明,NLR可以改善人口风险评估.
科学领域:
- 医学科学 医学科学 医学科学
- 临床研究 临床研究
- 流行病学 流行病学
背景情况:
- 炎症是心血管疾病 (CVD) 和癌症发展的关键因素.
- 一般人群中中性粒细胞与淋巴细胞比率 (NLR) 的预后值尚未得到充分确立.
研究的目的:
- 调查NLR与死亡风险之间的关联.
- 评估NLR在患有或没有心血管疾病,心力衰竭 (HF) 或癌症的个体中的预测能力.
主要方法:
- 使用国家卫生服务记录进行回顾性队列研究.
- 包括50岁以上的个人,按健康状况分类 (癌症,高血压,心血管疾病,心血管风险因素或没有).
- 从2014-2015年至2019年12月追踪的死亡率数据.
主要成果:
- 总共分析了223,388名个人.
- 在所有健康群体中,较高的NLR四分位数始终与死亡率的增加有关.
- 对于最高NLR四分位数的危险比率 (HR) 从1.87到2.30不等,经过对共变量进行调整.
结论:
- 升高的NLR与成人死亡风险增加有关,不论心血管疾病,高血压或癌症状况如何.
- NLR可以作为一个有价值的生物标志物来增强现有的人口风险预测模型.
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