环境和母亲对婴儿肠道代谢发育的影响
Kine Eide Kvitne1, Celeste Allaband2, Jennifer C Onuora3
1Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California, San Diego, La Jolla, CA, USA.
孟加拉国早期婴儿肠道微生物组和代谢组的发展显示,微生物衍生的胆胺和N-脂随着年龄的增长而增加. 环境因素和分娩方式显著影响婴儿代谢概况.
科学领域:
- 微生物学 微生物学
- 代谢学 代谢学 代谢学
- 人类发展 人类发展
背景情况:
- 早期生命对免疫和代谢发育至关重要.
- 这些发展模式在低收入和中等收入国家没有得到充分研究.
研究的目的:
- 描述孟加拉国母婴双胞胎在生命的前六个月中的微生物组和代谢组.
- 了解母亲和环境因素对婴儿肠道发育的影响.
主要方法:
- 在55个孟加拉国母婴双中分析微生物组和代谢组.
- 使用多组学分析来识别微生物-代谢物关系.
- 分析婴儿代谢概况与诸如分娩方式和水处理等因素之间的关联.
主要成果:
- 观察到与年龄相关的微生物衍生的胆胺和N-脂的增加,与胆盐化酶/转移酶 (bsh) 基因有关.
- 确认了母体便播种,但强调了对婴儿微生物组的重大环境贡献.
- 确定了婴儿代谢概况和分娩方式,母乳,家庭资产和水处理之间的关联.
- 剖腹产和未经处理的水与暂时的代谢变化有关,包括胆氨酸和N-脂的增加.
结论:
- 生命早期的环境和母亲的情况通过微生物组显著塑造了肠道代谢的发展.
- 具体的微生物-代谢物关系通过多omics分析来阐明.
- 这些发现强调了研究婴儿在全球不同环境中的发育的重要性.
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