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相关实验视频

Updated: Jan 10, 2026

Establishment of Gastric Cancer Patient-derived Xenograft Models and Primary Cell Lines

Establishment of Gastric Cancer Patient-derived Xenograft Models and Primary Cell Lines

Published on: July 19, 2019

使用不同维度的胃癌模型的比较In Vitro.

Wenhui Zheng¹, Yubiao Lin¹, Lulin Ji²

¹Oncology Department, Xiamen Haicang Hospital, Xiamen, China.

Cancer reports (Hoboken, N.J.)

|November 27, 2025

概括

三维胃癌 (GC) 模型,包括球体和器官,比2D培养更好地模仿人类瘤. 器官体表现出更高的生长率和耐药性,而球体体表现出最低的药物敏感性,为GC模型开发提供了信息.

关键词:

药物测试药物测试药物测试药物测试胃癌胃癌是一种胃癌.有机体有机体是有机的有机物球形形状的球形状可行性测试活力测试

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A Biomimetic Model for Liver Cancer to Study Tumor-Stroma Interactions in a 3D Environment with Tunable Bio-Physical Properties

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Last Updated: Jan 10, 2026

Establishment of Gastric Cancer Patient-derived Xenograft Models and Primary Cell Lines

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Published on: July 19, 2019

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科学领域:

在瘤学瘤学.
生物医学工程生物医学工程
癌症研究癌症研究

背景情况:

胃癌 (GC) 是一种常见的恶性瘤,通常在晚期被诊断出来.
需要先进的实验模型来提高药物疗效,个性化治疗,并了解GC的分子病理学.

研究的目的:

为了比较胃癌的二维,球形和器官形模型.
评估不同GC培养模型中的生长特征,药物敏感性和分子机制.
推进开发更有效的胃癌模型.

主要方法:

利用了四个胃癌细胞系和来自患者的瘤细胞 (PDTC).
评估细胞生长,药物敏感性,并进行RNA测序分析.
对比2D培养物,球形体和有机体.

主要成果:

3D模型 (球体和有机体) 与2D模型相比,更接近人类瘤组织结构.
有机体表现出最高的生长率,与PI3K/PTEN通路激活和减少亡有关.
球体表现出最低的药物敏感性和最高的代谢相关分子表达,这表明与有机体和2D模型相比,药物耐药性增加.

结论:

在2D,球形和器官模型之间存在显著的差异,涉及生长,结构,亡,信号通路和药物敏感性.
这些发现突出了不同培养系统中GC细胞的独特生物行为.
该研究为选择和开发最佳胃癌模型的研究和治疗开发提供了关键的见解.