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尿道和组织黑碳及其对移植受体功能的影响
Leen Rasking1, Kenneth Vanbrabant1, Liesa Engelen1
1Centre for Environmental Sciences, Hasselt University, Diepenbeek, Belgium.
Environmental pollution (Barking, Essex : 1987)
|November 27, 2025
概括
接受脏移植的接受者接触黑碳 (BC) 纳米粒子与脏损伤有关. 尿路BC水平较高与球体和管状损伤标志物增加相关,突出显示了对移植健康的环境影响.
科学领域:
- 环境健康 环境健康
- 腎臟病學 (nephrology) 是一種醫學.
- 毒理学 毒理学 毒理学
背景情况:
- 空气污染,特别是黑碳 (BC) 纳米粒子,越来越多地被认为对脏健康有不利影响.
- 移植脏的接受者代表了一个易受环境影响的脆弱人群.
- 以前的研究表明,BC纳米颗粒可以进入尿液和脏组织,需要进一步调查它们对移植受体的影响.
研究的目的:
- 为了研究内部和外部空气污染暴露和脏移植接受者的脏功能之间的关联,移植后一年.
- 探索尿和组织BC水平和功能生物标志物之间的关系.
- 评估靠近主要道路对这一群体脏健康的影响.
主要方法:
- 该研究包括183名脏移植接受者,并进行了协议活检和24小时尿样.
- 组织和尿液中的黑碳 (BC) 量化了使用秒脉冲照明下的白光生成.
- 分析了功能生物标志物与模拟的PM2.5和BC,道路接近,并使用相关性和回归分析测量了组织和尿路BC.
主要成果:
- 尿路BC增加与尿路尿素,KIM-1,微蛋白和α-1-微球蛋白的升高显著相关,尿路肌素清除率降低.
- 组织BC显示边界关联与减少估计的膜过率 (eGFR).
- 远离主要道路的生活与下尿路KIM-1和尿路尿素减少有关,这表明功能有所改善.
结论:
- 在移植患者中,尿黑碳 (BC) 与生物标志物显著相关,这些生物标志物表明球和管状损伤.
- 环境因素,如靠近主要道路和随后的BC积累,影响移植后脏健康.
- 这些发现强调了监测移植接受者的环境暴露的重要性,以保持移植功能.
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