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酸盐交叉连接的水凝使局部化疗免疫疗法能够重塑三阴性乳腺癌的免疫微环境

Rong Liu¹, Jia-Yi Chen², Cai-Mei Wang³

¹NMPA Key Lab of Quality Control and Evaluation of Pharmaceutical Excipients, Guangdong Institute for Drug Control, Guangzhou 510663, China; School of Biomedical Sciences and Engineering, Guangzhou International Campus, South China University of Technology, Guangzhou 511442, China.

Journal of controlled release : official journal of the Controlled Release Society

|November 27, 2025

概括

使用水凝的局部化疗免疫疗法增强了三阴性乳腺癌 (TNBC) 治疗的免疫细胞透. 这一策略同时提供多克索鲁比辛和αOX40抗体,在临床前模型中减少瘤复发和转移.

科学领域:

在瘤学瘤学.
免疫治疗是一种免疫疗法.
生物材料是一种生物材料.

背景情况:

三阴性乳腺癌 (TNBC) 免疫疗法的有效性依赖于免疫细胞透到瘤微环境 (TME).
TNBC通常表现为T细胞透率差,限制了治疗的成功.
开发增强T细胞在TME中的存在策略对于有效的癌症免疫疗法至关重要.

研究的目的:

开发一种局部化疗免疫疗法策略,以增强TNBC的抗瘤免疫力.
使用可注射水凝同时提供多克索鲁比辛 (DOX) 和αOX40抗体.
在临床前模型中评估本局化疗免疫疗法的治疗疗效.

主要方法:

开发一种酸乙烯交叉连接的凝,用于持续释放药物.
内注射的水凝同时提供DOX和αOX40抗体.
评估TME调节,免疫细胞透和在正体TNBC,术后乳腺癌和卵巢癌转移模型中的抗瘤反应.

主要成果:

水凝有效诱导了免疫细胞死亡,并增强了T细胞反应.
一次内注射将TME重塑到一个免疫刺激状态.
在TNBC模型中观察到显著抑制瘤复发,肺转移和延长生存时间.
在术后模型中,大约50%的小鼠实现了完整的瘤回归.
在卵巢癌模型中抑制腹膜转移的增长.

结论:

通过可注射水凝进行局部化疗免疫治疗是一种有前途的策略,可以增强抗瘤免疫力.
这种方法通过改善T细胞透和功能来提高癌症免疫治疗的疗效.
多功能水凝平台显示出治疗各种癌症的潜力,包括乳腺癌和卵巢癌.

关键词:

化学免疫疗法是一种化学免疫疗法.水凝是一种水凝.免疫原性细胞死亡术后管理术后管理三重阴性乳腺癌是什么?

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