在COPD中提前终止六分钟步行测试作为简单的预后标志物 vs. 波德指数 (BODE) 是一个指数
Chan Soo Youk1, Deog Kyeom Kim2, Chin Kook Rhee3
1Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Yeouido St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea.
在COPD患者中提前终止6分钟步行测试 (6MWT) 表明急性恶化和死亡风险增加. 这种简单的测试提供了可比于COPD结果的BODE指数的预后值.
科学领域:
- 肺部医学 肺部医学
- 临床结果研究研究
- 诊断标记物 诊断标记物
背景情况:
- 6分钟步行测试 (6MWT) 是评估COPD功能能力的标准.
- 6MWT在6分钟前提前终止可能表明潜在的系统脆弱性.
- 这项研究调查了COPD患者早期6MWT终止的预后意义.
研究的目的:
- 评估早期6MWT终止是否预测COPD的不良结果.
- 将6MWT早期终止的预后值与已建立的BODE指数进行比较.
- 评估6MWT早期终止与COPD恶化,死亡率和疾病进展的关联.
主要方法:
- 来自韩国多中心潜在的COPD队列 (2085名患者) 的数据分析.
- 早期终止定义为由于症状或临床决定,在6分钟前停止6MWT.
- 结局包括急性恶化,三年死亡率和FEV1,CAT和SGRQ-C得分的变化,使用回归,ROC曲线和倾向得分匹配进行分析.
主要成果:
- 早期6MWT终止发生在6.3%的患者中,与较低的FEV1和较高的症状负担相关.
- 早期终止显著增加了中度和重度COPD恶化的风险 (aIRR 1.60-2.39).
- 早期终止治疗的患者3年死亡率更高 (9.5%与4.6%相比),预后表现与BODE指数相比.
结论:
- 早期终止6MWT是一种可行的,简单的预测器,可预测COPD的不良结果.
- 这一发现提供了有价值的预后信息,特别是当全面评估是不可行的.
- 早期终止6MWT有助于COPD患者的风险分层.
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