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内分泌干扰剂与手术先天性形之间的关联:系统性审查和元分析

Núñez García Bernardo¹, Alvarez-García Natalia¹

¹Department of Pediatric Surgery, Hospital Universitari Parc Taulí, Sabadell, Spain; Institut d'Investigació i Innovació Parc Taulí (I3PT) CERCA Sabadell, Spain.

Journal of pediatric surgery

|November 27, 2025

概括

产前暴露于内分泌干扰物 (EDs) 与先天性形风险更高有关,特别是在男性泌尿器官和心脏系统. 这些发现强调了需要预防策略和更严格的法规来保护胎儿健康.

科学领域:

环境健康环境健康
儿科手术儿科手术
生殖毒理学生殖毒理学

背景情况:

产前暴露于内分泌干扰剂 (EDs) 是一个日益严重的公共卫生问题.
勃起障碍可以干扰胎儿关键的荷尔蒙发育,可能导致需要手术干预的先天性形.
本系统性审查涉及EDS与外科手术先天异常之间的关联.

研究的目的:

系统地审查和分析关于产前ED暴露和手术先天性形的观察性研究.
识别特定的ED和与风险增加相关的暴露窗口.
评估这些关联的证据质量.

主要方法:

按照PRISMA 2020指南进行系统审查和元分析.
在主要数据库 (PubMed,Embase,Web of Science) 和灰色文献 (2010-2025) 中进行了搜索.
包括关于酸盐,双,PFAS,有机和手术先天性形的观察性研究;使用纽卡斯尔-太华尺度和GRADE评估质量.

主要成果:

66项研究 (35,732名参与者) 符合纳入标准;64%的研究质量高.
在ED暴露和hypospadias,cryptorchidism和先天性心脏病之间发现了显著的关联.
第一个三个月的暴露显示出最强的联系;DEHP和DBP甲酸盐具有最大的泌尿器官形风险.

结论:

产前ED暴露显著增加了手术先天性形的风险,特别是男性泌尿器官和心脏异常.
这些发现支持实施产前预防策略和更严格的监管政策.
减少ED暴露对于保护胎儿健康和尽量减少儿科外科手术负担至关重要.

关键词:

双乙烯 A 是一种双乙烯.遗传性形遗传性形是一种先天性形.内分泌干扰物干扰内分泌干扰物一个繁荣的社会.儿科外科手术儿科外科手术甲酸的含量甲酸的含量产前暴露在产前暴露.

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