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Updated: Jan 10, 2026

Parallel Interrogation of β-Arrestin2 Recruitment for Ligand Screening on a GPCR-Wide Scale using PRESTO-Tango Assay
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Published on: March 10, 2020

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关于GPCR药物发现中的联体偏差的工业视角

James P Farmer1, James E Mason1, Nicholas D Holliday2

  • 1Excellerate Bioscience Ltd, NG2 Business Park, 21 The Triangle, Nottingham, NG2 1AE, UK.

Neuropharmacology
|November 27, 2025
PubMed
概括

设计偏向带有可能提高药物的疗效和减少副作用. 然而,开发这些向化合物带来了重大挑战,限制了它们目前在制药药物发现计划中的使用.

关键词:
这是一个偏见的偏见.药物发现 药物发现这是一种G蛋白质蛋白质,G蛋白质蛋白质.在GPCR中,GPCR是指GPCR.在体外 (in vitro) 的情况下.在生物体内,在生物体内.这是一种β-arrestin.

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