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Updated: Jan 10, 2026

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内皮中的S-化:NRF2和GSNOR损失的不同结果

Aleksandra Kopacz1, Damian Kloska2, Izabela Kraszewska2

  • 1Department of Medical Biotechnology, Faculty of Biochemistry, Biophysics and Biotechnology, Jagiellonian University, Krakow, Poland; Division of Regenerative Medicine, Hartman Institute for Therapeutic Organ Regeneration, Ansary Stem Cell Institute, Department of Medicine, Weill Cornell Medicine, New York, NY, USA.

Free radical biology & medicine
|November 27, 2025
PubMed
概括

内皮细胞 (EC) 的过早衰老涉及NRF2缺乏引发cGAS/STING通路. 在EC中,S-nitrosoglutathione降解酶 (GSNOR) 起着独特的作用,影响DNA释放和细胞完整性.

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