轮班工作与选择性脑容量损失有关:一项纵向研究
Thomas Welton1, Thomas Wei Jun Teo2, Seyed Ehsan Saffari3
1Department of Research, National Neuroscience Institute, Singapore; Neuroscience and Behavioural Disorders, Duke-NUS Medical School, Singapore.
NeuroImage
|November 27, 2025
概括
轮班工作与 thalamus 和 amygdala 中的大脑体积损失有关. 这种大脑体积损失在停止轮班工作后的2.4年内停止,这表明干预可以保护衰老的大脑.
科学领域:
- 神经科学是一个神经科学.
- 职业健康 职业健康 职业健康
- 衰老研究研究 衰老研究
背景情况:
- 全球的工作模式正在转向增加轮班工作和晚年就业.
- 轮班工作与睡眠障碍,认知障碍以及代谢和神经退行性疾病的风险增加有关,老化加剧了这些影响.
- 轮班工作对大脑的影响的神经支,特别是在衰老期间,还不太清楚.
研究的目的:
- 为了研究轮班工作和健康成年人的大脑结构之间的关系.
- 检查轮班工作中老年人的大脑结构如何随着时间的推移而变化.
主要方法:
- 基于人口的纵向队列研究的分析,包括14,198名参与者.
- 利用脑部MRI和关于健康,睡眠,认知和就业的自我报告问卷.
- 使用线性回归来比较2,122名轮班工人和12,076名非轮班工人在153个结构性大脑参数上,控制共变量.
主要成果:
- 与非轮班工人相比,轮班工人在右丘脑和左桃体中表现出对称的体积损失.
- 停止轮班工作的个人在2.4年内停止了这种体积损失.
- 二次分析表明特定白质道的微结构性降解以及体积损失和认知表现之间的负相关性.
结论:
- 轮班工作与 thalamus 和 amygdala 中选择性大脑体积损失有关.
- 这种体积损失是可逆的或在2.4年内停止轮班工作后停止.
- 监测,咨询和工作日程调整可能会减轻轮班工人的大脑体积损失.
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