在黎巴嫩的哨兵医院中对黄金葡萄球菌的综合抗生素检查数据:在脆弱,受冲突影响的环境中,呼吁制定优先的国家抗菌药物反应计划
Mariana Boulos1, Jame Tannous2, Rana Attieh1
1Department of Internal Medicine, Lebanese American University Medical Center-Rizk Hospital, Beirut, Lebanon.
概括
在黎巴嫩,抗菌素耐药性 (AMR) 正在增加,有大量的甲素耐药黄金葡萄球菌 (MRSA) 和多药耐药性感染. 迫切需要加强监督和控制战略.
科学领域:
- 临床微生物学 临床微生物学
- 传染性疾病 传染性疾病
- 公共卫生监督是对公共卫生的监督.
背景情况:
- 对抗生素耐药性 (AMR) 的监测对于国家控制战略至关重要.
- 由于资源限制和大量难民人口,黎巴嫩在常规AMR监测方面面临挑战.
- 黄金葡萄球菌 (S. aureus) 是临床感染的重要原因,但最近的国家敏感性数据有限.
研究的目的:
- 为提供黎巴嫩S. aureus耐药性模式的最新概述.
- 评估黄金色杆菌耐药性的时间趋势.
- 确定抵抗的区域差异,特别是在难民人口较多的地区.
主要方法:
- 在2017-2023年期间,来自13家黎巴嫩医院的综合抗生素图.
- 对6959个非重复的金黄色细菌分离物的分析.
- 临床微生物学实践和敏感性测试方法的文档.
主要成果:
- 甲素耐药黄金菌 (MRSA) 构成了37%的分离物.
- 在9.7%的隔离物体中观察到多重药物耐药性.
- 黄金菌血流感染的发生率显著增加,随着时间的推移,对多种抗生素类别的耐药性增加. 在难民密度较高的地区,发现MRSA患病率和耐药性较高.
结论:
- 增加甲素耐药性和S. aureus的多药耐药性需要采取紧急行动.
- 加强抗微生物药物管理和预防感染至关重要.
- 建立一个协调的国家AMR监测系统对于黎巴嫩至关重要.
更多相关视频
08:58Isolation and Identification of Waterborne Antibiotic-Resistant Bacteria and Molecular Characterization of their Antibiotic Resistance Genes
Published on: March 3, 2023
7.6K
09:59Application of the Intelligent High-Throughput Antimicrobial Sensitivity Testing/Phage Screening System and Lar Index of Antimicrobial Resistance
Published on: July 21, 2023
1.7K
相关概念视频
01:25Mechanism of Antibiotic Resistance in MRSA
Antibiotic resistance in bacteria arises when microorganisms evolve the ability to withstand drugs designed to kill them or inhibit their growth, rendering once-effective treatments useless. This phenomenon, driven by genetic change and selection under antibiotic exposure, poses a profound threat to modern medicine. Mechanisms include drug-inactivating enzymes (e.g., β-lactamases), efflux pumps that eject antibiotics, mutations altering antibiotic targets, decreased drug uptake, and acquisition...
01:25Clinical Significance of Antibiotic Resistance
Methicillin-resistant Staphylococcus aureus (MRSA) presents a critical public health threat, arising from its capacity to resist β-lactam antibiotics due to acquisition of the mecA gene within the staphylococcal cassette chromosome mec (SCCmec). This gene encodes penicillin-binding protein 2a (PBP2a), which impairs binding efficacy of methicillin and other β-lactams. MRSA has evolved into distinct clonal lineages impacting humans and animals alike, reinforcing its significance within the One...