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甲基A-C,来自Aspergillus sp.的三种未被描述的类,具有免疫抑制活性. 在TJ5077中,

Zhangrong Hou¹, Yeting Zhang¹, Abudula Yusuf²

¹Hubei Key Laboratory of Natural Medicinal Chemistry and Resource Evaluation, School of Pharmacy, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, Hubei Province, PR China.

|November 27, 2025

概括

研究人员从Aspergillus sp.中分离出了新的化物. 在TJ507上. 一些化合物表现出中度的免疫抑制活性,为新的免疫抑制药物开发提供了潜力.

科学领域:

自然产品化学自然产品化学
免疫学免疫学免疫学

背景情况:

菌代谢物是生物活性化合物的丰富来源.
亚斯伯吉洛菌种是众所周知的各种二次代谢产物的生产者,包括化物.

研究的目的:

从Aspergillus sp.中分离和描述新型化物. 在TJ507上.
评估分离化合物的免疫抑制潜力.

主要方法:

使用全面的光谱分析 (NMR,MS),化学衍生和电子圆二元化 (ECD) 计算,对类化合物的分离和结构阐明.
使用用抗CD3/抗CD28单克隆抗体 (mAbs) 或康卡纳瓦林A (ConA) 刺激的小鼠淋巴细胞评估免疫抑制活性.

主要成果:

确定了三种新的化物,阿斯帕尔卡尔A-C (1-3) 和两个已知的类似物 (4,5).
化合物2 - 4表现出中度的免疫抑制活性,IC50值在13.77 ± 2.73至21.37 ± 3.33μM之间.
通过光谱数据和ECD计算证实了结构阐明.

结论:

亚斯伯菌 sp. 的情况. TJ507产生了具有潜在免疫抑制特性的新类化合物.
化合物 2-4 代表了有希望的结构,用于开发新的免疫抑制剂.

关键词:

类化合物类化合物亚斯伯菌 sp. 的情况.具有免疫抑制活性的药物.结构阐明结构阐明

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