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相关概念视频

Epigenetic Regulation01:46

Epigenetic Regulation

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Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.
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Epigenetic Regulation01:37

Epigenetic Regulation

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Epigenetic changes alter the physical structure of the DNA without changing the genetic sequence and often regulate whether genes are turned on or off. This regulation ensures that each cell produces only proteins necessary for its function. For example, proteins that promote bone growth are not produced in muscle cells. Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.
X-chromosome...
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Genomic Imprinting and Inheritance02:30

Genomic Imprinting and Inheritance

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Diploid organisms inherit genetic material through chromosomes from both parents. Copies of the same gene are known as alleles. In most cases, both alleles are simultaneously expressed and allow various cellular processes to function optimally. If one of the alleles is missing or mutated, the expression of the other allele can compensate; however, this is not true for all genes.
The expression of some genes depends on which parent passed the gene to the offspring, through a phenomenon known as...
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Combinatorial Gene Control02:33

Combinatorial Gene Control

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Combinatorial gene control is the synergistic action of several transcriptional factors to regulate the expression of a single gene. The absence of one or more of these factors may lead to a significant difference in the level of gene expression or repression.
The expression of more than 30,000 genes is controlled by approximately 2000-3000 transcription factors. This is possible because a single transcription factor can recognize more than one regulatory sequence. The specificity in gene...
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Regulation of Expression at Multiple Steps01:23

Regulation of Expression at Multiple Steps

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The gene expression in cells is regulated at different stages: (i) transcription, (ii) RNA processing, (iii) RNA localization, and (iv) translation. Transcriptional regulation is mediated by regulatory proteins such as transcription factors, activators, or repressors—these control gene expression by initiating or inhibiting the transcription of genes. Once a precursor or pre-mRNA is produced, it undergoes post-transcriptional modification, including 5' capping, splicing, and the...
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Histone Modification02:32

Histone Modification

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The histone proteins have a flexible N-terminal tail extending out from the nucleosome. These histone tails are often subjected to post-translational modifications such as acetylation, methylation, phosphorylation, and ubiquitination. Particular combinations of these modifications form “histone codes” that influence the chromatin folding and tissue-specific gene expression.
Acetylation
The enzyme histone acetyltransferase adds acetyl group to the histones. Another enzyme, histone...
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Repressing Gene Transcription by Redirecting Cellular Machinery with Chemical Epigenetic Modifiers
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面向植物表观遗传控制的基于逻辑的框架.

Lingrui Zhang1, Jian-Kang Zhu2

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概括
此摘要是机器生成的。

植物表观基因组编辑提供可逆性特征控制,无需DNA变化. 将表观基因组编辑与合成基因电路集成,可以实现可编程,上下文意识的调节,用于可扩展的特征工程.

关键词:
克里斯普尔是什么意思?克里斯普尔是什么意思?编辑表观基因组编辑基因调节 基因调节 基因调节基因组编辑 基因组编辑宏观表观遗传学是指宏观表观遗传学.合成基因电路的合成基因电路

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科学领域:

  • 植物生物技术 植物生物技术
  • 合成生物学 合成生物学
  • 表观遗传学 在表观遗传学中,表观遗传学是指表观遗传学.

背景情况:

  • 基因组编辑精确但不可逆转,限制了它的应用.
  • 目前的表观基因组编辑工具缺乏动态监管能力.
  • 植物特征调节需要先进的,适应性的遗传控制机制.

研究的目的:

  • 调查新兴的植物表观基因组编辑技术.
  • 探索将表观基因组编辑与基于逻辑的合成基因电路集成.
  • 为可编程植物特征调节提出新的策略.

主要方法:

  • 审查当前的植物表观基因组编辑方式.
  • 对植物的逻辑门合成基因电路的概念设计.
  • 关于在Arabidopsis和Solanum lycopersicum中进行特定应用的建议.

主要成果:

  • 确定适合植物的表观基因组编辑方法.
  • 设计多重机驱动的开花开关和布尔逻辑门的果实成熟系统.
  • 开发用于植物表观基因组工程的路线图和缓解策略.

结论:

  • 将表观基因组编辑与合成逻辑相结合,可以实现可编程,上下文意识的调节.
  • 复合表观基因组工程为植物特征提供可扩展和预测的控制.
  • 这种方法将静态遗传修饰转化为动态的,适应性特征管理.