肠道微生物群的调节由乳糖菌 paracasei EFEL6501 改善肌肉缩
Geum Na Pyeon1, Hyunbin Seong1, Jin Seok Moon2
1Brain Korea21 Center for Smart GreenBio Convergence and Sustainable Regional Development, Division of Animal, Horticultural, and Food Sciences, Chungbuk National University, Cheongju 28644, Republic of Korea.
Journal of microbiology and biotechnology
|November 27, 2025
概括
乳糖菌虫 EFEL6501 (EFEL6501) 通过改善肌肉新陈代谢和肠道健康来预防肌肉缩. 这种益生菌在体外和体内表现出抗缩作用,增强肌肉质量和力量.
科学领域:
- 微生物学 微生物学
- 肌肉生理学 肌肉生理学
- 肠道微生物组研究研究
背景情况:
- 益生菌通过肠道微生物群和生物活性代谢物调节宿主健康.
- 肌肉缩是一个重要的健康问题,与肌肉退化和蛋白质损失有关.
研究的目的:
- 为了研究Lacticaseibacillus paracasei EFEL6501 (EFEL6501) 的抗缩作用.
- 评估EFEL6501在体外和体内对甲 (DEX) 诱导的肌肉缩的影响.
主要方法:
- 在体外研究中使用DEX处理的C2C12神经管.
- 在体内研究涉及EFEL6501在小鼠模型中的补充.
- 分析肌肉参数,蛋白质合成/降解途径和肠道微生物群组成.
主要成果:
- 在实验室中,EFEL6501代谢物减轻了肌肉降解,恢复了蛋白质合成.
- 在小鼠中,EFEL6501补充剂增加了肌肉厚度,握力和肌肉纤维CSA.
- EFEL6501调节肠道微生物群,增加有益细菌和酸盐水平,同时抑制蛋白质降解.
结论:
- 通过调节肌肉新陈代谢,EFEL6501显示出显著的抗缩作用.
- EFEL6501积极影响肠道微生物群的组成和功能.
- 作为一种功能性益生菌,EFEL6501显示出预防肌肉缩的潜力.
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