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定制晶体结构和能量调节路径,用于1600 nm以上的增强NIR-II发光成像
Shenghui Bi1,2,3, Yao Xu1,2, Zhixin Chen1,2
1School of Physics and Electronics, Key Laboratory of Low-dimensional Quantum Structures and Quantum Control of the Ministry of Education, Synergetic Innovation Center for Quantum Effects and Applications, Key Laboratory for Matter Microstructure and Function of Hunan Province, Institute of Interdisciplinary Studies, Hunan Normal University, Changsha, Hunan 410081, China.
Nano letters
|November 27, 2025
概括
研究人员开发了一种新的兴奋剂策略,以增强近红外IIb (NIR-IIb) 光学成像探头. 这种方法可以增加1600nm以上的发光度,以获得更深,更清晰的生物成像.
科学领域:
- 生物医学工程 生物医学工程
- 材料科学 材料科学 材料科学
- 光学成像技术的成像
背景情况:
- 第二次近红外 (NIR-II) 光学成像 (1000-1700nm) 能够通过低光子散射和深层组织透,实现非侵入性*in vivo*诊断.
- 目前的纳米探测器发射在1600nm以下,这限制了它们在需要更长波长的先进成像应用中的实用性.
研究的目的:
- 在NaLnF4:Yb/Tm纳米晶体中开发一种促进NIR-II发光度超过1600nm的一般策略.
- 创建高效的NIR-IIb (>1600nm) 纳米探针,用于高分辨率的生物医学成像.
主要方法:
- 采用 (Mn) 兴奋剂策略,在NaLnF4:Yb/Tm纳米晶体中诱导晶体结构转变 (六边形[β]到立方形[α]).
- 使用了声子能量调节和建立高效的图- (Tm-Mn) 能量转移.
- 进行了惰性涂层和核心外结构制造 (α-NaLuF4:Yb/Tm/Mn@NaLuF4),以增强发光.
主要成果:
- 与六边形β-NaLnF4.4相比,兴奋剂策略导致立方α-NaLnF4:Yb/Tm/Mn纳米晶体的1632nm辐射增加了100倍.
- 惰性涂层进一步增加了额外的4倍的发光.
- 使用开发的核心纳米探针,成功实现了肠道,血管和骨折的高分辨率NIR-IIb *in vivo*成像.
结论:
- 拟议的Mn兴奋剂策略是有效的显著增强NIR-IIb发光度超过1600nm.
- 开发的α-NaLuF4:Yb/Tm/Mn@NaLuF4核心外纳米探针显示了先进的生物医学成像的巨大潜力.
- 这项工作为设计高效的NIR-IIb纳米探针用于病理诊断提供了一种新的方法.
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