潜伏结核病感染与辅助生殖结果之间的关联:系统性审查和元分析
Zikang Sheng1,2, Lin Zeng1,3, Yue Zhang1,2
1Peking University Third Hospital, Beijing, China.
BMJ open
|November 27, 2025
概括
潜伏性结核感染 (LTBI) 可能会增加在接受辅助生殖的不育患者中流产的风险. 在临床怀孕或活产率方面没有发现显著差异,但由于证据有限,建议谨慎.
科学领域:
- 生殖医学 生殖医学
- 传染性疾病 传染性疾病
- 公共卫生 公共卫生
背景情况:
- 结核病 (TB) 是导致不孕症的一个重要原因,特别是在高患病率地区.
- 潜在结核病感染 (LTBI) 对辅助生殖结果的影响尚未得到充分证实.
研究的目的:
- 系统地审查和对有或没有LTBI接受辅助生殖的不孕患者的妊娠结果进行元分析.
- 评估临床怀孕,流产和活产率的差异.
主要方法:
- 对病例控制或队列研究进行系统审查和元分析.
- 在PubMed,Embase和Web of Science进行了搜索.
- 使用纽卡斯尔-太华尺度评估研究质量;使用固定效应模型进行元分析.
主要成果:
- 包括四项研究. 在LTBI组中,流产率明显高 (OR1.14;p=0.049).
- 在临床怀孕 (OR 0.98;p=0.692) 或活产率 (OR 0.96;p=0.305) 中没有显著差异.
- 大多数结果的低异质性;由于研究的局限性,证据的确定性较低.
结论:
- 患有LTBI的不育患者在辅助生殖后可能会出现更高的流产率.
- 临床怀孕和活产率没有显著差异.
- 需要进一步的高质量研究来证实这些发现.
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