荷尔蒙避孕药和自杀行为风险:瑞典全国范围的基于登记册的研究
Jurate Aleknaviciute1, Donghao Lu2, Vide Gotby2
1Department of Psychiatry, Erasmus Medical Center, Rotterdam, Zuid-Holland, Netherlands.
BMJ open
|November 27, 2025
概括
荷尔蒙避孕药的使用,特别是非口服孕激素类型,与女性,特别是青少年的自杀行为风险增加有关. 口服避孕药和组合配方在整体上没有增加风险.
科学领域:
- 生殖健康 生殖健康
- 精神病学是一个精神病学.
- 药物监督 药物监督 药物监督
背景情况:
- 荷尔蒙避孕药被生育年龄的女性广泛使用.
- 了解它们与心理健康结果 (如自杀行为和抑郁症) 的关联,对于患者的安全至关重要.
研究的目的:
- 研究使用荷尔蒙避孕药与随后的自杀行为和抑郁症风险之间的关联.
- 在不同类型的荷尔蒙避孕药和不同年龄组中检查这些风险.
主要方法:
- 在瑞典,一项基于登记的全国性队列研究.
- 包括从2006年到2013年超过200万名女性.
- 利用考克斯回归模型来分析来自健康和死亡登记册的数据.
主要成果:
- 使用口服避孕药或联合非口服配方时,没有发现自杀行为的风险增加.
- 非口服仅含孕激素的避孕药与自杀行为风险增加有关 (HR=1.17).
- 青少年使用口服避孕药或组合配方显示自杀行为风险增加,与成年人不同. 非口服仅含孕激素的避孕药在青少年和成年人中都有增加的风险.
结论:
- 虽然口服和联合避孕药没有显示整体风险增加,但非口服仅含孕激素的配方需要注意.
- 在青春期使用荷尔蒙避孕药和非口服孕激素唯一避孕药时观察到的风险增加需要进一步调查.
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