双相情感障碍患者的慢性大麻使用与与健康参与者相比,与可比的决策和功能结果有关
Alannah Miranda1, Benjamin Z Roberts1, Breanna M Holloway1
1Department of Psychiatry, University of California San Diego, San Diego, US.
Translational psychiatry
|November 27, 2025
概括
与非使用者相比,双相情感障碍 (BD) 患者使用大麻可能会改善决策和功能能力. 然而,大麻使用会损害健康个体的决策能力.
科学领域:
- 神经科学是一个神经科学.
- 精神病学是一个精神病学.
背景情况:
- 双极性障碍 (BD) 与决策能力和功能能力受损有关.
- 据事报道,大麻使用 (CU) 可以缓解BD患者的这些认知症状.
研究的目的:
- 调查大麻使用与BD和健康对照 (HC) 个体的决策/功能能力之间的关联.
- 测试BD患者的CU是否与与不使用HC参与者相比,与决策和功能能力相关.
主要方法:
- 招募了87名参与者 (HC和BD) 定期 (≥4x/周) 的CU或没有CU.
- 使用爱荷华州博任务评估决策.
- 使用UCSD基于绩效的技能评估 (UPSA-2) 评估功能能力.
主要成果:
- CU与HC参与者的决策能力受损有关.
- 在BD参与者中,CU与非用户的更好的决策相关,并且与非CUHC参与者相比.
- 在BD参与者的CU也与与非CUHC参与者相比的UPSA-2得分有关.
结论:
- 大麻使用可能会使双相情感障碍患者的决策和功能能力正常化.
- 需要进一步的研究来探索基于大麻素的治疗方法,用于BD的认知缺陷.
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