人体内核的非侵入性超声波神经调节影响奖励灵敏度
Siti N Yaakub1,2, John Eraifej3,4,5, Nadège Bault1,2
1School of Psychology, Faculty of Health, University of Plymouth, Plymouth, UK.
Nature communications
|November 27, 2025
概括
无创性横超声刺激 (TUS) 有效调节深层大脑活动,影响学习和决策,就像深层大脑刺激 (DBS) 一样. 这项研究证实TUS是精确,非侵入性神经调节深层大脑区域的一个有前途的工具.
科学领域:
- 神经科学是一个神经科学.
- 神经调节是一种神经调节.
- 认知科学 认知科学
背景情况:
- 深度大脑刺激 (DBS) 提供精确的神经调节,但具有侵入性.
- 开发用于深度大脑调制的非侵入性方法对于神经科学和治疗学至关重要.
研究的目的:
- 研究跨超声波刺激 (TUS) 对于深部大脑目标的非侵入性神经调节的疗效.
- 评估TUS对神经活动和学习和决策任务中的行为的影响.
主要方法:
- 在26名健康成年人身上进行了个体内TUS-fMRI实验.
- 参与者接受了针对腹核 (NAcc),背前环状皮质 (dACC) 或Sham刺激的TUS.
- 在fMRI获取后刺激过程中执行了一项概率强化学习任务.
主要成果:
- 针对NAcc的TUS显著改变了与奖励期望相关的血氧水平依赖 (BOLD) 反应.
- 核心 accumbens (NAcc) TUS调节奖励相关的行为,包括赢-停留策略和学习率.
- 观察到的神经和行为测量效应与NAcc的深度大脑刺激 (DBS) 诱导的效应相当.
结论:
- 超超声刺激 (TUS) 是一种可行的非侵入性方法,用于调节深层大脑活动.
- 在神经科学研究和潜在的临床应用中,TUS为神经调节的侵入性技术提供了一个有希望的替代方案.
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