太空辐射诱导明显的衰老现象型:对太空旅行的影响
Louise E Pitcher1, Bipasha Mukherjee2, Ashley M Saathoff1
1Masonic Institute on the Biology of Aging and Metabolism and Department of Biochemistry, Molecular Biology and Biophysics, University of Minnesota, Minneapolis, MN, USA.
npj aging
|November 27, 2025
概括
太空辐射,与玛射线不同,通过引起细胞衰老来加速衰老. 由于地球磁场减弱,这种细胞衰老对宇航员和全球人口构成健康风险.
科学领域:
- 天体生物学 天体生物学
- 细胞生物学 细胞生物学
- 辐射生物学 辐射生物学
背景情况:
- 地球的磁场正在减弱,增加了对太空辐射的暴露.
- 由高能离子组成的太空辐射会导致显著的DNA和细胞损伤.
- 衰老细胞 (SnCs) 的积累与多病症和衰老有关.
研究的目的:
- 研究太空辐射与玛辐射对人类纤维细胞的差异效应.
- 分析辐射诱导的细胞衰老背后的分子机制.
- 评估老年治疗药物对太空辐射诱导的衰老的疗效.
主要方法:
- 人体纤维细胞暴露于各种形式的太空辐射和玛辐射.
- 评估与衰老相关的表型 (形态变化,SA-β-gal染色).
- 大量和单细胞RNA测序 (scRNAseq) 用于转录造型.
- 用来自辐射SnCs和老年治疗药物的条件介质对细胞进行处理.
主要成果:
- 与玛辐射相比,太空辐射在人类纤维细胞中诱导了更大的衰老相关的表型.
- scRNAseq揭示了空间辐射细胞中综合应激反应和氧化还原代谢途径的上调.
- 辐射SnCs的条件介质在健康细胞中诱导了益炎特征,这取决于辐射类型和细胞类型.
- 疗剂在初级皮肤纤维细胞中表现出辐射特异性作用.
结论:
- 与玛辐射相比,太空辐射不同地诱导细胞衰老.
- 辐射诱导的衰老可能会导致太空旅行的病原性影响.
- 了解这些影响对于减轻与太空探索和地球相关的健康风险至关重要.
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