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Updated: Jan 10, 2026

Clonal Analysis of Embryonic Hematopoietic Stem Cell Precursors Using Single Cell Index Sorting Combined with Endothelial Cell Niche Co-culture
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克隆性血液形成的人体血蛋白质谱

Zhi Yu1,2,3, Amélie Vromman4, Ngoc Quynh H Nguyen5

  • 1Clinical and Translational Epidemiology Unit, Massachusetts General Hospital, Boston, MA, USA.

Nature communications
|November 27, 2025
PubMed
概括

与不确定潜力的克隆性血液形成 (CHIP) 相关的等离子体蛋白质组概况揭示了免疫和炎症途径的关联. 这些发现为CHIP提供了洞察力.

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Blood plasma is a fluid that contains approximately 92% water and 8% solutes. The solutes include various types of proteins, which constitute about 7% of the total solutes in the plasma. The high-molecular-weight proteins—albumins, globulins, and fibrinogen—are essential to plasma function. Albumins, making up about 60% of the plasma proteins, maintain the osmotic balance within blood vessels by preventing excessive water leakage. Additionally, albumins serve as carrier proteins,...
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Hematopoiesis, or blood cell production, is a vital biological process that begins early in embryonic development and continues throughout life. This process generates the various types of cells found in blood, including red blood cells, white blood cells, and platelets from hematopoietic stem cells (HSCs).
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