在早期精神病中,认知网络连接的依赖阶段的模式
XiaoChen Tang1,2,3, YanYan Wei1,2, JiaoYan Pang4
1Shanghai Key Laboratory of Psychotic Disorders, Shanghai Mental Health Center, Shanghai Jiaotong University School of Medicine, Shanghai, China.
Nature communications
|November 27, 2025
概括
认知网络的脱差和一般认知因子 ("g"因子) 的下降是早期精神病的关键特征. 这项研究分析了第一发精神分裂症患者和临床精神病高风险患者的认知功能.
科学领域:
- 神经科学是一个神经科学.
- 精神病学是一个精神病学.
- 认知心理学 认知心理学
背景情况:
- 在早期精神病中,认知障碍很普遍.
- 以前的研究主要集中在孤立的认知缺陷上,而不是跨领域的关系.
- 了解认知网络连接可能会揭示早期精神病背后的机制.
研究的目的:
- 研究早期精神病中的认知网络连接和一般认知因子 ("g"因子).
- 与健康对照组 (HC) 相比,探索认知分离和"g"因子下降在第一次精神分裂症 (FES) 和临床高风险 (CHR) 组之间的关系.
主要方法:
- 在2518名参与者 (988名FES,767名CHR,763名HC) 中评估了认知功能,使用中国版本的测量和治疗研究以改善精神分裂症认知能力共识认知电池 (MCCB).
- 用确认式因子分析来检查g因子和域间的相关性.
主要成果:
- 观察到一个依赖于阶段的认知"脱差"模式,从HC (0.28) 到CHR (0.33) 到FES (0.40) 的平均域间相关性增加.
- 在所有组中确定了一个共同的"g"因子,但与CHR和HC组相比,其强度在FES组显著降低.
- "g"因子的下降与增加的认知网络连接性和更强的域间相关性相关.
结论:
- 认知网络的脱差和g因子的下降是早期精神病的重要特征.
- 这些发现表明,认知网络组织的改变在早期精神病的病理生理学中至关重要.
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