血尿素水平与临界急性缺血性中风患者的死亡率之间的关联
Liqun Hao1, Xuezhi Chen2, Lin Zhu2
1The First Clinical College of Medicine, Shandong University of Traditional Chinese Medicine, Jinan, 250013, Shandong, China.
在重症急性缺血性中风 (AIS) 患者中血尿 (BUN) 的升高独立预测了更高的死亡风险. 这种关联在没有慢性病 (CKD) 的患者中特别强烈.
科学领域:
- 腎病學和神經病學.
- 关键护理医学 关键护理医学
- 生物标志物研究 生物标志物研究
背景情况:
- 急性缺血性中风 (AIS) 是导致死亡和残疾的主要原因.
- 确定严重病情的AIS患者可靠的预后标志物对于风险分层至关重要.
- 在这个人群中,血液尿素 (BUN) 摄入的预后值尚未完全阐明.
研究的目的:
- 调查入院BUN水平与AIS重症患者死亡率之间的关联.
- 确定BUN是否作为这个队列中死亡率的独立预测因素.
- 探索慢性病 (CKD) 对BUN.UN的预后效益的影响.
主要方法:
- 使用MIMIC-IV数据库进行回顾性队列研究.
- 患者根据入院BUN水平分为四分之一.
- 进行了多变量考克斯回归和受限立方线分析,并对相关共变量进行了调整.
主要成果:
- 升高的BUN独立地与30天,90天和180天死亡率的增加有关.
- 在BUN水平和死亡风险之间观察到线性剂量反应关系.
- 在非CKD患者中,BUN显示出显著的预后价值,在CKD患者中相关性较弱.
结论:
- 入院BUN是AIS重症患者死亡率的独立预测因素.
- 在风险分层方面,BUN提供了宝贵的预后实用性,特别是在没有CKD的患者中.
- 建议进行进一步的前性研究,以验证这些发现并探索潜在的机制.
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