相关实验视频
Updated: Jan 10, 2026

10:42
Oral Biofilm Sampling for Microbiome Analysis in Healthy Children
Published on: December 31, 2017
17.8K
抑郁症与口腔微生物群的关联
Fei Liu1, Yang Yang2, Ning Zhang2
1Department of neurology, Affiliated Hangzhou First People's Hospital, School of Medicine, Westlake University, Zhejiang, 310, 006, Hangzhou, China.
Scientific reports
|November 27, 2025
概括
口腔微生物群的多样性在轻度和重度之间有所不同. 特定的细菌种类与抑郁症的严重程度相关,这表明口腔健康和心理健康之间存在联系.
科学领域:
- 微生物组研究的研究.
- 精神病学是一个精神病学.
- 口腔健康 口腔健康
背景情况:
- 肠-大脑轴突出了肠道微生物群在抑郁症中的作用.
- 患有牙周病的患者表现出较高的抑郁症状.
- 口腔微生物群与抑郁症严重程度之间的特定关系需要进一步研究.
研究的目的:
- 探索口腔微生物组成和多样性与抑郁症严重程度之间的关联.
- 研究抑郁症患者口腔微生物群和全身炎症因素之间的相关性.
主要方法:
- 32名患有抑郁症的患者被分为轻度 (PHQ-9 ≤14) 和重度 (PHQ-9 >14) 抑郁症组.
- 分析了口腔微生物多样性 (α和β) 和组成.
- 评估了细菌种类,抑郁症严重程度 (PHQ-9分数) 和炎症标志物之间的相关性.
主要成果:
- 在轻度和重度抑郁组之间观察到口腔微生物α-多样性 (Shannon,Simpson) 和β-多样性 (未加权和加权UniFrac) 的显著差异.
- 一些细菌种群,包括Actinobacteria和Peptostreptococcaceae,与抑郁症严重程度有积极的相关性.
- 两组之间没有发现系统性炎症因子的显著差异.
结论:
- 口腔微生物群的组成和多样性与抑郁症严重程度有显著的关联.
- 特定的口腔细菌种群可能在抑郁症的表现或进展中发挥作用.
- 在这种口腔微生物群与抑郁症的联系中,全身炎症的参与需要进一步的研究.
相关概念视频
Depression: Overview
750
Depression is a prevalent mental illness marked by persistent sadness and lack of interest in previously enjoyable activities. It can take several forms, including major depression, persistent depressive disorder, and bipolar I and II disorders. Symptoms range from emotional changes like chronic worry to physical changes like sleep disturbances and suicidal thoughts. From a neurobiological perspective, depression is believed to be triggered by abnormalities in the brain's prefrontal cortex,...
750
Depressive Disorders: Etiology
415
Depressive disorders result from a complex interplay of biological, psychological, and sociocultural factors, each contributing uniquely to the development and persistence of the condition. Understanding these factors provides critical insight into the multifaceted nature of depression.
Biological Factors in Depression
Biological predispositions significantly influence the risk of developing depressive disorders. Genetic studies highlight the role of variations in the serotonin transporter...
Biological Factors in Depression
Biological predispositions significantly influence the risk of developing depressive disorders. Genetic studies highlight the role of variations in the serotonin transporter...
415
Long-term Depression
33.0K
Long-term depression, or LTD, is one of the ways by which synaptic plasticity—changes in the strength of chemical synapses—can occur in the brain. LTD is the process of synaptic weakening that occurs over time between pre and postsynaptic neuronal connections. The synaptic weakening of LTD works in opposition to synaptic strengthening by long-term potentiation (LTP) and together are the main mechanisms that underlie learning and memory.
33.0K
Long-term Depression
3.0K
Long-term depression, or LTD, is one of the ways by which synaptic plasticity—changes in the strength of chemical synapses—can occur in the brain. LTD is the process of synaptic weakening that occurs over time between pre and postsynaptic neuronal connections. The synaptic weakening of LTD works in opposition to synaptic strengthening by long-term potentiation (LTP) and together are the main mechanisms that underlie learning and memory.
Calcium Ion Concentration Mechanism
If over...
Calcium Ion Concentration Mechanism
If over...
3.0K
Depressive Disorders: MDD and Dysthymia
581
Depressive disorders are a group of mental health conditions characterized by pervasive feelings of sadness, diminished pleasure in life, and a significant impact on daily functioning. These conditions are most prevalent in individuals during their 30s and affect women at twice the rate of men. Contrary to popular belief, younger individuals are generally more susceptible to these disorders than older adults. Two key types of depressive disorders include Major Depressive Disorder (MDD) and...
581
Assessment of the Mouth
974
A thorough mouth assessment, including inspection and palpation of the lips, gums, tongue, tonsils, uvula, and pharynx, is crucial in detecting potential health issues. Diseases ranging from oral cancer to systemic conditions like diabetes could be identified early through careful oral examination. This article provides a detailed guide on conducting a comprehensive mouth assessment.
Mouth Inspection
The inspection begins with visually examining the mouth for symmetry, color, and size.
Mouth Inspection
The inspection begins with visually examining the mouth for symmetry, color, and size.
974

