饮食中的酸负荷及其与所有原因死亡率,心血管死亡率和事件的关联
Niloufar Abdollahpour1,2, Nadia Homayounfar1, Nioosha Samadi1
1Department of Nutrition, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
Scientific reports
|November 27, 2025
概括
通过PRAL和DAL评估的中度饮食酸荷载与心血管疾病 (CVD) 死亡风险增加有关. 这一发现表明一种非线性关系,风险在适度摄入水平达到顶峰,这需要进一步研究饮食中的酸平衡和心血管疾病.
科学领域:
- 心血管健康 心血管健康
- 营养流行病学 营养流行病学
- 代谢健康 代谢健康
背景情况:
- 饮食中的酸负荷越来越被认为是影响代谢健康的因素.
- 以前的研究已经探讨了饮食和心血管疾病 (CVD) 之间的联系,但饮食酸荷重的具体作用需要进一步阐明.
- 了解饮食中的酸负荷对心血管疾病死亡率的影响对于公共卫生建议至关重要.
研究的目的:
- 调查饮食酸载量指标 (NEAP,PRAL,DAL) 与心脏病发病率,心脏病死亡率和全因死亡率之间的关联.
- 探索饮食中的酸负荷与心血管疾病死亡率之间的潜在非线性关系.
- 提供关于饮食酸平衡在伊朗人口心血管健康中的作用的见解.
主要方法:
- 来自MASHAD研究的前性队列研究,涉及6482名35-65岁的成年人.
- 使用净内源性酸产量 (NEAP),潜在脏酸负荷 (PRAL) 和食酸负荷 (DAL) 评估的食酸负荷.
- 多变量考克斯回归和非线性受限立方线模型用于分析十年后续期的关联.
主要成果:
- 潜在的酸载荷 (PRAL) 和食酸载荷 (DAL) 与第二和第三四分位数中心血管疾病死亡率的增加有关.
- 净内源性酸产量 (NEAP) 仅在第二个四分位数中显示出与心血管疾病死亡率的关联.
- 非线性限制立方线模型证实了PRAL (P=0.004) 的显著非线性关系和DAL (P=0.009) 的中级关联,在中等水平处具有峰值风险.
结论:
- 适度的饮食酸性负载,特别是PRAL和DAL所表明的,可能与心血管疾病死亡率的风险增加有关.
- 观察到的非线性关系表明,高和潜在的低食酸负载都可能产生不良影响,中等水平构成最高风险.
- 需要进一步的研究来证实这些发现,并了解与饮食中的酸负荷与心血管疾病死亡率相关的潜在机制.
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