在乳腺癌中,夜间缺氧和认知功能之间的联系
Clara Elia1, Joy Perrier1, Mylène Duivon1,2
1Université de Caen Normandie, Inserm, EPHE-PSL, PSL University, CHU de Caen, GIP Cyceron, U1077, NIMH, Caen, 14000, France.
Scientific reports
|November 27, 2025
概括
乳腺癌患者比健康人群更容易出现夜间缺氧和认知问题. 然而,夜间缺氧在这个研究小组中没有显著影响认知表现.
科学领域:
- 神经学 神经学
- 在瘤学瘤学.
- 睡眠医学 睡眠医学
背景情况:
- 认知投诉在乳腺癌 (BC) 患者中很普遍.
- 睡眠呼吸障碍 (SDB),特别是夜间缺氧,与一般人群的认知能力下降有关.
- 晚间缺氧和BC患者的认知之间的关系仍未得到充分研究.
研究的目的:
- 研究乳腺癌患者的夜间缺氧和认知表现之间的关联.
- 在BC患者和健康对照者 (HCs) 之间比较夜间缺氧患病率和认知功能.
主要方法:
- 用氧度计的家庭门诊多睡眠学来评估夜间缺氧.
- 参与者填写了问卷和认知测试.
- 统计分析包括威尔科克森测试和多变量模型,调整焦虑和抑郁.
主要成果:
- 与HC患者相比,BC患者的夜间缺氧和主观认知抱怨率较高 (p <0.05).
- 客观认知测试没有显示BC组的显著损伤.
- 在BC患者的夜间缺氧和认知表现之间没有发现显著的关联.
结论:
- 夜间缺氧在BC患者中比HC患者更常见,但可能不是这一队列认知表现问题的主要驱动因素.
- 治疗方式 (无化疗的放射治疗/内分泌治疗) 可能有助于尽管有投诉,但保持认知功能.
- 需要进一步的研究来阐明BC幸存者的认知变化的多因素性质.
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