在前列腺癌患者中辐射诱导的毒性背后的免疫因素:系统性审查
Lucas Mose1,2, Hady Aboelroos1, Adam Zabini1
1Department of Radiation Oncology, Inselspital, Bern University Hospital, University of Bern, Bern, 3010, Switzerland.
Discover oncology
|November 27, 2025
概括
这份综述强调,虽然预测前列腺癌辐射毒性的免疫因素研究有限,但互白素-6 (IL-6),互白素-2 (IL-2),瘤坏死因子-α (TNF-α) 和淋巴细胞计数显示出确定有风险的患者的希望.
科学领域:
- 在瘤学瘤学.
- 免疫学 免疫学 免疫学
- 辐射疗法 辐射疗法
背景情况:
- 放射治疗 (RT) 是前列腺癌的标准治疗方法.
- 一部分患者经历了影响生活质量的长期副作用.
- 确定辐射诱导毒性的预测因素至关重要.
研究的目的:
- 系统地审查在接受RT的前列腺癌患者中与辐射诱导的毒性相关的免疫因素的文献.
- 为了确定潜在的生物标志物来预测治疗毒性.
主要方法:
- 在PubMed,Web of Science和Scopus进行了全面的文献搜索.
- 包括报告前列腺癌患者接受RT的毒性和免疫因素的研究.
- 研究质量使用纽卡斯尔-太华质量评估量表 (NOS) 进行评估.
主要成果:
- 分析了15项涉及1237名患者的研究,其RT方式和患者特征各不相同.
- 关于免疫学因素和预测生物标志物的报告很少,没有结论.
- 介质素-6 (IL-6),介质素-2 (IL-2),瘤缩因子-α (TNF-α) 和淋巴细胞计数与RT诱导的毒性最一致相关.
结论:
- 对前列腺癌中RT诱导毒性的免疫学预测因子的研究是有限的和高度可变的.
- IL-6,IL-2,TNF-α和淋巴细胞计数是预测RT后毒性的最一致的标志物.
- 需要进一步的研究来验证这些发现并改善患者的治疗结果.
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