通过比较cNORM和LMS方法,从生物识别数据中估计参考百分位曲线
Ronja Laurenz1, Wolfgang Lenhard2
1Institute of Psychology, Ruprecht-Karls-University, Heidelberg, Germany.
Scientific reports
|November 27, 2025
概括
为了创建生物识别参考曲线,我们比较了Lambda Mu Sigma (LMS) 方法和cNORM. cNORM在极端百分位数方面表现出卓越的精度,这对于公共卫生查至关重要.
科学领域:
- 生物统计学 生物统计学
- 公共卫生 公共卫生
- 增长曲线分析 增长曲线分析
背景情况:
- 准确的生物识别参考曲线对于人口健康监测和查至关重要.
- 兰巴达穆西格玛 (LMS) 方法是生成特定年龄参考百分位数的标准.
- 需要使用替代方法来提高准确性,特别是在极端范围.
研究的目的:
- 为了比较Lambda Mu Sigma (LMS) 方法的性能与cNORM,一种无分布方法,用于建模生物识别参考曲线.
- 通过使用NHANES数据,在不同的百分位数范围内评估这两种方法的准确性和偏差.
- 确定cNORM作为公共卫生应用中LMS的替代品的适用性.
主要方法:
- 使用了国家健康和营养检查调查 (NHANES) 数据集.
- 对比Lambda Mu Sigma (LMS) 和cNORM方法的身体质量指数 (BMI) 和最大氧气消耗 (VO2max) 参考曲线.
- 使用随机抽样,交叉验证和性能指标 (R2,RMSE,Bias).
主要成果:
- 无论是cNORM还是LMS,在完整的BMI和VO2max分布中都表现出很高的准确性.
- cNORM在极端百分位数 (±2 SD) 中表现出卓越的精度,这对于识别有风险的个体至关重要.
- 精度随着更大的样本大小而提高,对于LMS有更明显的效果,尽管相互作用不一致.
结论:
- 无分发cNORM方法是用于公共卫生参考曲线的LMS的可行替代方案.
- 当精确的分类在极端范围对于选至关重要时,cNORM特别有利.
- 这项研究强调了基于生物识别数据的准确健康查方法选择的重要性.
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