层的骨数字表型的遗传学和与骨骨折和偏差的相关性
Moh Sallam1, Lina Göransson2, Anne Larsen2
1Department of Animal Biosciences, Swedish University of Agricultural Sciences (SLU), Box 7023, S-750 07, Uppsala, Sweden.
Genetics, selection, evolution : GSE
|November 28, 2025
概括
基因选择可以通过减少骨骨折来改善产母的福利. 对X射线图像的自动分析为骨几何学提供了可遗传的表型,使育种者能够选择更健康的骨头并减少骨折.
科学领域:
- 动物遗传学动物遗传学
- 动物生理学 动物生理学
- 生物技术是生物技术.
背景情况:
- 产卵母被遗传选择为高产卵,导致诸如骨骨折 (影响高达80%) 等福利问题.
- 精确,自动化和可遗传的表型是需要对基因选择对骨骨折.
- 这项研究解决了识别和量化遗传性骨特征的挑战.
研究的目的:
- 开发自动化放射图像分析,用于骨表型化.
- 评估这些自动化表型与骨骨折和偏差的遗传性和遗传相关性.
主要方法:
- 1051只产卵母的X光成像 (波万斯棕色,洛曼棕色).
- 深度学习模型用于自动化基骨细分和测量几何和辐射透明度.
- 使用50K Illumina SNP芯片和多特征基因组限制的最大概率进行基因参数估计的基因造型.
主要成果:
- 切割后部偏差和骨折的遗传率为0.280.30.
- 自动化表型的遗传性在0.070.10 (辐射透明度) 和0.110.39 (几何) 之间.
- keel 几何和骨折/偏差之间的遗传相关性在 -0.57 到 0.72.7 之间.
结论:
- 成功开发了用于测量基尔骨辐射透明度和几何学的自动化方法.
- 基尔凸区域是一种可遗传的表型,对育种计划有用,以减少基尔骨问题.
- 这些方法可以适应其他骨头和物体,支持对改善骨健康的住房和营养的大规模研究.
更多相关视频
09:34A Method to Estimate Cadaveric Femur Cortical Strains During Fracture Testing Using Digital Image Correlation
Published on: September 14, 2017
7.7K
06:49Analysis of Cell Differentiation, Morphogenesis, and Patterning During Chicken Embryogenesis Using the Soaked-Bead Assay
Published on: January 12, 2022
3.6K
相关概念视频
00:49Complementation Tests
6.0K
A complementation test is a simple cross to identify whether the two mutations are located on the same gene or different genes. It was first performed by Edward Lewis in the 1940s while working on fruit flies. He developed the test to identify the location and arrangement of different mutations on chromosomes.
Organisms heterozygous for different mutations are crossed pairwise in all combinations. If present on different genes, the mutations can complement each other by providing the missing...
Organisms heterozygous for different mutations are crossed pairwise in all combinations. If present on different genes, the mutations can complement each other by providing the missing...
6.0K
02:41Lethal Alleles
17.6K
Agouti: A Lethal Allele
Lucien Cuénot discovered lethal alleles in 1905 while studying the inheritance of coat color in mice. The agouti gene is responsible for the color of the coat in mice. This gene codes for an agouti-signaling protein, which is responsible for melanin distribution in mammals. The wild-type allele gives rise to gray-brown coat color in mice, while the mutant allele gives rise to yellow coat color. In addition to coat color, the agouti gene is associated with the yellow...
Lucien Cuénot discovered lethal alleles in 1905 while studying the inheritance of coat color in mice. The agouti gene is responsible for the color of the coat in mice. This gene codes for an agouti-signaling protein, which is responsible for melanin distribution in mammals. The wild-type allele gives rise to gray-brown coat color in mice, while the mutant allele gives rise to yellow coat color. In addition to coat color, the agouti gene is associated with the yellow...
17.6K
01:09Changes in the Appendicular Skeleton with Age
3.3K
The upper and lower limb initially develops as a small bulge called a limb bud, which appears on the lateral side of the early embryo. The upper limb bud appears near the end of the fourth week of development, with the lower limb bud appearing shortly after.
Initially, the limb buds consist of a core of mesenchyme covered by a layer of ectoderm. The ectoderm at the end of the limb bud thickens to form a narrow crest called the apical ectodermal ridge. This ridge stimulates the underlying...
Initially, the limb buds consist of a core of mesenchyme covered by a layer of ectoderm. The ectoderm at the end of the limb bud thickens to form a narrow crest called the apical ectodermal ridge. This ridge stimulates the underlying...
3.3K
02:27Background and Environment Affect Phenotype
7.4K
Although the genetic makeup of an organism plays a major role in determining the phenotype, there are also several environmental factors, such as temperature, oxygen availability, presence of mutagens, that can alter an organism’s phenotype.
An example of how genetic background affects phenotype can be seen in horses. The Extension gene in horses is responsible for their coat color. A wild-type gene (EE) produces black pigment in the coat, while a mutant gene (ee) produces red pigment. A...
An example of how genetic background affects phenotype can be seen in horses. The Extension gene in horses is responsible for their coat color. A wild-type gene (EE) produces black pigment in the coat, while a mutant gene (ee) produces red pigment. A...
7.4K