注射性硬化疗法危及视力的并发症:病例报告,文献综述和FAERS数据库分析
Dehai Liu1, Xiaona Wang1, Hongliang Dou2
1Department of Ophthalmology, Beijing Key Laboratory of Restoration of Damaged Ocular Nerve, Peking University Third Hospital, Beijing, China.
BMC ophthalmology
|November 28, 2025
概括
对血管形的聚多卡诺尔硬化疗法可能会导致严重的视力丧失. 一个儿科病例的渐进性眼动脉闭塞 (OAO) 导致不可逆转的失明,突出了这种程序的风险.
科学领域:
- 眼科医生 眼科 眼科
- 血管外科 血管外科
- 皮肤病学 皮肤病学
背景情况:
- 聚多卡诺尔注射硬化疗法是常见的血管疾病,如血瘤.
- 虽然通常是安全的,但有报道罕见但严重的眼部并发症,包括失明.
研究的目的:
- 报告一名儿科患者在聚多卡诺尔硬化疗法后出现的眼动脉渐进性阻塞 (OAO) 的独特病例.
- 分析与硬化剂相关的眼部并发症的风险和严重程度.
主要方法:
- 一名13岁的男孩因面部血管瘤而接受了超声波引导的聚多卡诺注射.
- 分析了临床过程,多式成像 (基底摄影,OCT,光素血管学,多普勒超声波) 和药监数据.
主要成果:
- 患者经历了暂时的视力丧失,在一个月内与OAO一起进展到不可逆转的失明.
- 药监测显示,眼部并发症罕见 (3.9%),但严重 (45.7%严重不良事件),6.2%的病例永久失明.
结论:
- 聚多卡诺醇硬化疗法带有灾难性的眼部并发症的风险,包括永久失明.
- 建议在关键血管结构附近进行硬化剂注射时非常小心,因为对阳性OAO的治疗选择有限.
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