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预测丰富使用生物标志物在研究的严重疾病患者的败血症:一个系统性审查

Logan R Van Nynatten^1,2, Diyaa Bokhary³, Michelle Yee Suet Wong³

¹Division of Critical Care Medicine, Department of Medicine, Schulich School of Medicine and Dentistry, Western University, London, ON, Canada. Logan.VanNynatten@lhsc.on.ca.

Critical care (London, England)

|November 28, 2025

概括

在败血症患者的临床试验中使用的生物标志物可以提高试验效率. 使用suPAR和IL-6等生物标志物的研究表明有好处,这表明这种方法可以增强败血症治疗研究.

科学领域:

关键护理医学关键护理医学
临床试验的设计
发现生物标志物的发现.

背景情况:

败血症是重症监护室入院的主要原因,死亡率高.
对败血症治疗药物的随机试验由于患者人群异质性而取得了有限的成功.
使用生物标记物的预测丰富可以通过识别可能从干预中受益的患者子组来提高临床试验的有效性.

研究的目的:

在涉及败血症患者的随机对照试验 (RCT) 中系统地审查用于预测丰富的生物标志物的应用.
总结这些RCT的特征,生物标志物,丰富策略和结果.

主要方法:

按照PRISMA-ScR指南进行系统审查.
搜索了OVID Medline,Embase和Cochrane控制试验的中央注册表.
包括使用分子生物标志物进行预测丰富的成年败血症患者的RCT.
研究特征,生物标志物,策略和结果的叙述总结;使用Cochrane工具评估偏差风险.

主要成果:

包括12个RCT,使用基于血液的蛋白质或脂多糖标记物进行丰富.
五项研究 (42%) 报告了统计学上显著的初级结局影响,其中三项显示了患者重要的益处 (死亡率/严重性降低).
生物标志物suPAR,AT,mHLA-DR,IL-6和EAA在试验中被使用,这些试验证明了免疫,抗微生物或凝血疗法的益处.

结论:

基于生物标志物的预测丰富表明,它有望提高临床试验在重症败血症患者的效率.
尽管研究异质,生物标志物丰富策略信号改善试验结果.
进一步探索,调查和验证用于重症监护试验设计的生物标志物是有必要的.

关键词:

生物标志物生物标志物危急的疾病危急的疾病预测丰富的预测丰富蛋白质组学是指蛋白质组学.败血症这是一种败血症.

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