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对DNA甲基化,种族和经济不平等以及空气污染的表观基因组范围的分析

Sarah Holmes Watkins^1,2, Christian Testa^3,4, Andrew J Simpkin⁵

¹Population Health Sciences, Bristol Medical School, University of Bristol, Bristol, UK. s.h.watkins@bristol.ac.uk.

Clinical epigenetics

|November 28, 2025

概括

结构性种族主义和空气污染与DNA甲基化变化有关,可能导致健康不平等. 这项研究探讨了这些暴露如何成为生物体,影响健康结果.

科学领域:

环境表观遗传学环境表观遗传学
社会流行病学社会流行病学
基因组学就是基因组学.

背景情况:

基因甲基化 (DNAm) 是调节基因表达的关键表观遗传机制,对环境和社会暴露有反应.
健康不平等可能源于不良暴露的生物体现,包括结构歧视和环境污染物.
很少有表观基因组范围的关联研究 (EWAS) 研究了结构性和生命周期暴露对DNAm的影响.

研究的目的:

测试DNA甲基化调解种族歧视,经济逆境和空气污染的生物体现的假设.
检查与结构性种族主义和环境暴露相关的DNAm模式,在不同的美国人口中.

主要方法:

在两个基于人口的队列中进行了横截面的表观基因组范围的关联研究 (EWAS):我的身体我的故事 (MBMS) 和动脉样硬化多民族研究 (MESA).
在非西班牙裔黑人,非西班牙裔白人和西班牙裔个人血液样本中使用Illumina EPIC和450k BeadChip数组测量了全基因组DNAm.
评估暴露,包括与交通有关的空气污染 (黑碳,氧化),结构性种族歧视和经济逆境.

主要成果:

与交通相关的空气污染和DNAm网站之间观察到最强烈的关联,这表明与炎症相关的表观遗传变化.
在DNAm变异和结构性种族歧视措施之间发现了有意义的关联,包括吉姆·克劳州的出生地和种族化的经济住宅隔离.
确定了与歧视相关的特定DNAm位点 (例如,在ZNF286B和FUT6中),位于具有合理健康影响的基因中.

结论:

基因甲基化作为一个生物机制,通过它结构性种族主义和不公平分配的空气污染成为体现.
这些体现的暴露可能有助于健康不平等的发展.
使用各种组织进行进一步的复制研究是有必要的,以证实这些发现.

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