预后营养指数与败血症患者90天死亡率之间的关联:一项回顾性队列研究

Mingjie Xie^1,2, Liuyun Huang^1,2, Ling Li^1,2

¹Department of Critical Care Medicine, The First Affiliated Hospital of Guangxi Medical University, Nanning, China.

BMC nutrition

|November 28, 2025

概括

预后营养指数 (PNI) 与败血症患者的90天死亡率相反相关. 较高的PNI水平与死亡风险降低相关,这表明它可以作为预后工具.

科学领域:

关键护理医学关键护理医学
营养科学营养科学
生物统计学生物统计学

背景情况:

败血症是一种危及生命的器官功能障碍,是由宿主对感染的反应失调引起的.
评估败血症患者的预后对于及时干预和改善结果至关重要.
预后营养指数 (PNI) 是一种随时可用的生物标志物,反映了营养状况和炎症反应.

研究的目的:

研究诊断性营养指数 (PNI) 与被诊断患有败血症的患者90天死亡率之间的关联.
探索PNI与败血症相关死亡率之间的潜在非线性关系.
评估PNI作为败血症患者的预后标志物.

主要方法:

使用MIMIC-IV数据库中的数据进行回顾性队列研究.
包括5786名被诊断患有败血症的患者.
采用多变量Cox比例危险模型和受限立方线 (RCS) 分析来评估PNI和90天死亡率之间的关联.

主要成果:

整体90天死亡率为35.0%.
较高的PNI与90天死亡率降低的风险显著相关 (调整后HR=0.99,P=0.004).
限制性立方线分析显示,PNI和90天死亡率之间存在显著的非线性反向关系 (P < 0.001).

结论:

普尼表明,在败血症患者中,与90天死亡率有显著的非线性反向关联.
PNI可以作为一种有价值的预后工具,用于识别高风险败血症患者.
这些发现支持PNI的潜在使用,以指导有针对性的干预措施,并改善败血症管理中的临床结果.

关键词:

这就是MIMIC-IV.死亡率死亡率死亡率预测营养指数的预测.败血症这是一种败血症.

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