在中年和老年人中,估计的葡萄糖处置率变化与复合结局之间的关联:一项国家队列研究
Weiyi Zhou1, Guangdong Wang2, Yaxin Zhang3
1Graduate School, Nanjing Medical University, Nanjing, Jiangsu, China.
估计葡萄糖处置率 (eGDR) 的下降与老年人中较高的复合结局 (CKO) 风险有关. 较高的累积eGDR水平显著降低了CKO风险,突出了其对早期病评估的潜力.
科学领域:
- 腎臟病學 (nephrology) 是一種醫學專業.
- 代谢健康 代谢健康
- 流行病学 流行病学
背景情况:
- 通过估计的葡萄糖处置率 (eGDR) 表示的胰岛素抵抗在代谢健康方面越来越令人担忧.
- 慢性病 (CKD) 构成了重大的公共卫生挑战,需要早期检测和风险分层方法.
研究的目的:
- 调查eGDR变化与中年和老年人复合结局 (CKO) 风险之间的关联.
- 评估累计eGDR对CKO的预测性能.
主要方法:
- 来自中国健康与退休长度研究 (CHARLS) 的4007名参与者的分析.
- 使用腰围,HbA1c和高血压估计的eGDR;CKO定义为CKD或功能迅速下降 (RKFD).
- 使用后勤回归,限制立方线和ROC曲线分析来评估关联和预测值.
主要成果:
- 累计eGDR和CKO风险 (OR=0.96) 之间观察到一个线性,反向的关系.
- 累计eGDR的最高四分位数显示,与最低四分位数 (OR=0.47) 相比,CKO的风险降低了53%.
- 累积的eGDR表现出比基线eGDR和传统的胰岛素抵抗指数更好的预测性能,其中HbA1c和高血压是主要贡献者.
结论:
- 长期的eGDR下降与CKO风险增加有显著的关联.
- 累积的eGDR显示为早期评估CKD风险的有价值生物标志物具有前途.
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