基于磁共振成像的合成计算机断层扫描对头部和部光子和质子疗法的剂量评估
Marte Kåstad Høiskar1, René M Winter1, Natalie Hornik1,2
1Department of Physics, Norwegian University of Science and Technology, Trondheim, Norway.
合成CT (sCT) 显示了光子疗法的潜力,但对头癌的质子疗法有局限性. 与计划CT相比,使用sCT进行质子剂量计算的剂量测量精度降低了.
科学领域:
- 放射治疗 物理 物理
- 医疗成像医学成像
- 在瘤学瘤学.
背景情况:
- 准确的目标划分对于精确的质子疗法治疗至关重要.
- 只有磁共振成像 (MRI) 的工作流程需要可靠的合成计算机断层扫描 (sCT) 来准确计算剂量.
- 评估sCT的准确性对于推进仅用MRI进行放射治疗至关重要.
研究的目的:
- 评估基于商业软件的sCT用于头癌 (HNC) 中的质子剂量计算的剂量测量精度.
- 为了比较sCT对质子剂量计算的准确性与同一sCT上的光子剂量计算.
- 将sCT的性能与传统的规划CT (pCT) 进行比较.
主要方法:
- 获得了20名HNC患者的MRI和pCT.
- 使用商业软件生成基于MRI的sCT,并将其与pCT共同注册.
- 在pCT和sCT上创建和重新计算光子和质子图,分析剂量体积直方图 (DVH) 度量和马指数 (2%/2毫米).
主要成果:
- 大多数结构的pCT和sCT计算剂量之间的DVH指标的中位数差异为<0.4 Gy.
- 质子图表显示了一些差异,特别是食道,口腔和喉的平均剂量.
- 光子计划的马传递率 (GPR) 中位数为>97.7%,质子计划为>93.3% (低剂量值时的体GPR除外).
结论:
- 虽然sCT对于光子疗法是可行的,但它与对质子剂量计算的pCT的协议较差.
- 质子剂量计算中的差异可能部分归因于CT和MRI之间的患者定位差异.
- 需要进一步的研究来优化sCT,以便准确的质子疗法规划.
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