职业吸入剂暴露和患类风湿性关节炎的风险:系统性审查和元分析
Qianwen Liu1, Xin Song2, Emily Mauro3
1Department of Clinical Neuroscience, Karolinska Institutet, and Center for Molecular Medicine, Karolinska University Hospital, Stockholm, Sweden.
Arthritis & rheumatology (Hoboken, N.J.)
|November 28, 2025
概括
职业吸入剂暴露,包括二氧化和石棉,与患类风湿性关节炎 (RA) 的风险更高有关. 这凸显了需要采取工作场所安全措施,以防止RA.
科学领域:
- 类风湿病学 类风湿病学
- 职业健康 职业健康 职业健康
- 环境医学 环境医学
背景情况:
- 类风湿性关节炎 (RA) 是一种慢性自身免疫性疾病,具有吸烟等已知的危险因素.
- 职业吸入剂暴露对RA发展的影响不太清楚.
- 这项研究解决了有关工作场所吸入剂和RA风险的知识差距.
研究的目的:
- 系统地审查和综合有关职业吸入剂暴露与类风湿性关节炎 (RA) 风险之间的相关证据.
- 量化与各种职业吸入剂相关的RA风险.
- 为工作场所预防策略和未来研究提供信息.
主要方法:
- 一个系统的审查和元分析,遵循PRISMA指南.
- 在Medline,Embase和Web of Science数据库中进行了搜索.
- 包括基于人口的横截面,病例控制和队列研究,具有可靠的RA确定和暴露数据.
主要成果:
- 对25项涉及10种类型职业吸入剂的研究进行了元分析.
- 对于二氧化,石棉,溶剂,农药,肥料,动物灰尘和发动机废气,发现了显著的RA风险增加 (RR 1.25-1.49).
- 在七个元分析中发现了中等到高的异质性.
结论:
- 职业吸入剂暴露与风湿性关节炎的风险增加有关.
- 工作场所的预防策略对于减轻RA风险至关重要.
- 对将吸入物与RA联系起来的生物机制进行进一步的研究是有必要的.
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