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Updated: Jan 10, 2026

A Customizable Approach for the Enzymatic Production and Purification of Diterpenoid Natural Products
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Published on: October 4, 2019

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伪天然产品IDO1抑制剂和降解剂的设计,合成和结构演变

Xiu-Fen Cheng1, Belén Lucas1, Philipp Lampe2

  • 1Abteilung Chemische Biologie, Max-Planck-Institut für Molekulare Physiologie, Otto-Hahn-Straße 11, 44227, Dortmund, Germany.

Angewandte Chemie (International ed. in English)
|November 28, 2025
PubMed
概括

研究人员通过结合类和类碎片来开发伪天然产品 (PNPs). 这些新型化合物, (-) - 墨-罗利丁PNP,有效地抑制和降解胺-2,3-二氧化酶1 (IDO1),在癌症治疗中显示出希望.

关键词:
双循环单烯 是一种双循环单烯.生物物理特性表征同结晶的洞察力 同结晶的洞察力IDO1 抑制剂和降解剂.罗利丁类类化合物

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