在癌症预防和管理中重新评估omega-3 (EPA/DHA)
Alessio Molfino1,2, Maurizio Muscaritoli2, Federica Tambaro2
1Department of Interdisciplinary Studies on WellBeing, Health and Environmental Sustainability (BeSSA).
Current opinion in clinical nutrition and metabolic care
|November 28, 2025
概括
欧米茄-3脂肪酸在癌症预防和缓解缓解症方面表现有前途. 虽然eicosapentaenoic acid (EPA) 与降低结直肠癌风险有关,但对其他结果的益处需要进一步研究.
科学领域:
- 在瘤学瘤学.
- 营养科学 营养科学
- 分子生物学分子生物学
背景情况:
- 欧米茄-3多不和脂肪酸 (PUFA) 是一种可能在癌症中起作用的必需脂肪. 新出现的证据突出了它们对癌症护理各方面的影响.
- 了解EPA和DHA等不同omega-3的具体作用对于有针对性的应用至关重要.
研究的目的:
- 审查瘤学中关于omega-3PUFAs的最新证据.
- 焦点领域包括癌症预防,黄昏症,治疗毒性和治疗反应.
主要方法:
- 对最近的流行病学,生物标志物和临床研究进行系统审查.
- 对omega-3脂肪酸,癌症风险,缓冲症管理和治疗副作用的数据进行分析.
主要成果:
- 在EPA和结直肠癌风险之间存在一致的反向关联;DHA的证据不太清楚.
- 富含omega-3的饮食 (地中海,MIND) 与降低癌症风险有关.
- 补充剂在癌症缓解症 (体重,炎症,生活质量) 中显示出好处,但对瘦体质量有不同的影响.
- 有望减少口腔粘膜炎;由于研究异质性,对神经病变和化学敏感性没有明确的结果.
结论:
- 欧米茄-3脂肪酸在瘤学中具有可证明的生物学和临床效应.
- 利益取决于背景,需要进一步调查.
- 未来的研究应该标准化干预措施,分层患者,并将omega-3纳入免疫营养,用于精确瘤学.
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