肠-大脑轴和外体介导的通信在术后认知功能障碍与结直肠癌相关的结直肠癌
Ying Gao1, Biao Xi1, Yang Zhang1,2
1Department of Anesthesiology, the First Affiliated Hospital of Bengbu Medical University, Bengbu 233004, China.
Acta biochimica et biophysica Sinica
|November 28, 2025
概括
结直肠癌手术后的术后认知功能障碍 (POCD) 与肠道细菌的变化有关. 微生物外体可能会触发大脑细胞中的铁亡,导致认知能力下降.
科学领域:
- 神经科学是一个神经科学.
- 微生物学 微生物学
- 在瘤学瘤学.
背景情况:
- 手术后认知功能障碍 (POCD) 是结直肠癌 (CRC) 手术后的一种严重并发症,影响记忆,注意力和情绪.
- 目前对POCD缺乏干预措施,需要对其潜在机制进行研究.
- 现有研究表明,肠道微生物群失调和认知缺陷之间存在联系,但确切的途径尚不清楚.
研究的目的:
- 为了研究肠道微生物群衍生出外体样纳米颗粒在POCD的发病过程中的作用.
- 探索涉及海马神经元中自性依赖性铁亡的潜在机制.
主要方法:
- 利用CRC的老鼠模型来检查肠道微生物群的组成.
- 分析了从这些老鼠的肠道微生物群中获得的外体.
- 在外体暴露后评估神经元铁亡标记物 (ATG5,COX2,GPX4,FTH1).
主要成果:
- CRC大鼠表现出改变的肠道微生物群,其多样性减少.
- 来自微生物群的外体被神经元所吸收.
- 外体诱导神经元中的铁亡标志物,通过增加ATG5/COX2和减少GPX4/FTH1.1.表示.
- 建立了微生物失调,铁和认知衰退之间的机械联系.
结论:
- 在CRC中肠道微生物群失调有助于POCD.
- 来自肠道微生物的外体样纳米颗粒介导海马神经元中的铁亡.
- 这一途径为CRC相关的POCD提供了潜在的治疗点.
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