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Updated: Jun 25, 2026

Antimicrobial Peptides Produced by Selective Pressure Incorporation of Non-canonical Amino Acids
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关于谷氨酸域交换对皮帕斯塔丁产生影响的研究

Mengxi Wang1, Jie Zheng1, Wenqing Li1

  • 1Key Laboratory of Food Processing and Quality Control, College of Food Science and Technology, Nanjing Agricultural University, Nanjing 210000, PR China.

ACS synthetic biology
|November 28, 2025
PubMed
概括

工程 Bacillus subtilis lipopeptide 通过 plipastatin 合成中的域交换来生产,显著提高了产量. 这种优化增强了农业和保存中的抗微生物应用.

关键词:
在NRPS工程方面,NRPS工程域名交换 域名交换皮帕斯塔提因与皮帕斯塔提因是不同的.发起人工程工程 发起人工程

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Production of Pharmaceuticals01:30

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Industrial insulin production uses genetically engineered E. coli expressing a proinsulin gene controlled by a tryptophan promoter and containing a methionine linker for later cleavage. The cells also carry ampicillin resistance for selective growth. Seed cultures are stored at −80 °C and production begins by thawing a small amount to inoculate starter cultures, which are progressively scaled to a 50,000-L bioreactor. In the bioreactor, E. coli grow in nutrient-rich media under sterile, tightly...