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唐奈康配方通过调节SHIP2/PI3K/AKT通路来缓解糖尿病病中的细胞损伤

Tao Yang^1,2, Yongxin Huang², Wenjing Li²

¹Dongfang Hospital, Beijing University of Chinese Medicine, Beijing, China.

Journal of diabetes research

|November 28, 2025

概括

唐奈康 (TNK) 通过改善功能和减少细胞损伤,保护糖尿病病 (DN). 它在小鼠模型和细胞培养中调节SHIP2/PI3K/AKT通路.

科学领域:

药理学药理学是指药理学的学科.
腎臟病學 (nephrology) 是一種醫學.
传统中国医药传统中国医药

背景情况:

糖尿病病 (DN) 是糖尿病的一种主要并发症,其特征是细胞损伤.
传统中医 (TCM) 配方正在探索在管理DN的潜在治疗益处.
唐奈康 (TNK) 是一种TCM配方,研究其对DN的保护作用.

研究的目的:

调查TangNaikang (TNK) 在减轻糖尿病脏病 (DN) 中的 podocyte 损伤中的保护机制.
使用体内和体外模型阐明TNK治疗效果所涉及的分子途径.

主要方法:

使用UPLC-Q-TOF/MS.识别了TNK和含有TNK的血清的化学成分.
网络药理学被用来分析TNK在治疗DN的机制.
db/db小鼠和高葡萄糖诱导的MPC5细胞被用作实验模型,以评估TNK对功能,组织病理和与细胞损伤和PI3K/AKT通路相关的蛋白质表达的影响.

主要成果:

TNK由69种化合物组成,含有TNK的血清含有34种已识别的化合物.
在db/db小鼠中,TNK治疗显著改善了血清脂质概况和脏结构/功能.
TNK调节了细胞关联蛋白 (SYNPO,nephrin,CD2AP,podocin) 和PI3K/AKT通路蛋白 (PI3K,AKT,SHIP2,IRS2,GLUT4) 在脏组织和MPC5细胞中的表达.

结论:

唐纳康 (TNK) 改善了糖尿病脏病 (DN) 和高葡萄糖诱导的细胞损伤中的细胞损伤.
通过调节SHIP2/PI3K/AKT信号通路来调节TNK的保护作用.

关键词:

通过PI3K/AKT路径.飞船2号是第二艘船.唐纳伊康 (TangNaikang) 是一个国家.糖尿病性脏病糖尿病脏病葡萄细胞受伤的损伤.

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