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临床特征和肠道微生物群的改变高血压个体与左心室缩

Liang Cai¹, Guo-Qiang Liu¹, Chun-Mei Zeng^2,3

¹Guangxi Medical University, Nanning, Guangxi, China.

Frontiers in microbiology

|November 28, 2025

概括

带有左心室缩 (LVH) 的高血压与明显的代谢变化和肠道微生物组变化有关. 识别这些肠道微生物群生物标志物可以帮助控制高血压和预防器官损伤.

科学领域:

心脏病学心脏病学
微生物学微生物学
代谢学代谢学代谢学

背景情况:

高血压是心血管疾病的主要原因之一.
左心室缩 (LVH) 是高血压的常见并发症,表明目标器官受损.
肠道微生物群的变化越来越多地被认为是各种疾病的促成因素,包括心血管疾病.

研究的目的:

为了确定潜在的高血压与LVH的诊断生物标志物.
描述与高血压和LVH相关的临床特征和肠道微生物群概况.
探索肠道微生物群组成和高血压患者的代谢异常之间的关系.

主要方法:

将参与者分为三组:高血压 (高血压与LVH),非高血压 (高血压没有LVH) 和健康对照.
记录临床参数,包括身体质量指数 (BMI),尿酸,甘油三,同素,估计的淋巴膜过率和高密度脂蛋白胆固醇.
分析便样本以检测肠道微生物的多样性,丰富性和分布在不同的分类层 (族群,属,物种).

主要成果:

患有高血压和LVH的患者显示BMI,尿酸,甘油三,同型半氨酸和γ-谷氨基转移酶升高,估计淋巴膜过率降低和高密度脂蛋白胆固醇.
与对照组相比,在LVH组中观察到Actinobacteria丰度的显著减少.
布劳蒂亚 (Blautia) 属被丰富了,而白血球菌 (Streptococcus equinus) 在LVH患者中更为丰富. 肠道微生物群标志物显示出对LVH的良好诊断潜力.

结论:

患有LVH的高血压与特定的代谢障碍和改变肠道微生物群组成有关.
肠道微生物群的变化,包括特定属和物种的变化,可以作为高血压相关目标器官损伤的潜在生物标志物.
这些发现表明,通过调节肠道微生物组,在高血压患者中预防和管理LVH的新途径.

关键词:

临床指标临床指标我们的肠道微生物群.高通量测序的高通量测序这种高血压,高血压.左心室缩症是指左心室缩症.

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