综合肠道微生物组和代谢学分析揭示了过敏性鼻炎中的微生物-代谢交叉对话
Guangchen Sun1,2, Shouyan Zhao3, Hehua Huang1
1Department of Respiratory Medicine, General Hospital of Northern Theater Command, Shenyang, Liaoning, China.
Frontiers in microbiology
|November 28, 2025
概括
过敏性鼻炎与肠道失调和改变的微生物代谢物有关. 这项研究揭示了特定的细菌和代谢变化,表明了针对肠道微生物群的治疗方法来治疗过敏性鼻炎.
科学领域:
- 微生物组研究的研究.
- 免疫学 免疫学 免疫学
- 代谢学 代谢学 代谢学
背景情况:
- 新出现的证据表明,肠道失生症和过敏性鼻炎 (AR) 病变之间存在联系.
- 肠道微生物群在AR进展中的确切作用需要进一步研究.
- 用一种综合的多omics方法来研究AR患者的肠道微生物组成和代谢概况.
研究的目的:
- 为了研究过敏性鼻炎患者的肠道微生物组成和代谢特征.
- 探索肠道微生物群和AR进展之间的机制联系.
- 基于肠道微生物群调节来确定AR的潜在治疗点.
主要方法:
- 来自23名AR患者和15名健康对照的便样本的16S rRNA基因测序.
- 不针对性的代谢分析,以识别微生物代谢产物.
- 斯皮尔曼的等级相关性分析,以评估微生物群-代谢物相互作用.
主要成果:
- 抗炎症患者的肠道微生物群落结构发生了变化,产生SCFA的细菌 (例如,Faecalibacterium) 和富含的促炎性种群 (例如,Fusobacterium) 枯竭.
- 代谢分析显示了松托酸和CoA生物合成,糖解和pyruvate代谢等途径的显著干扰.
- 综合性分析确定了特定细菌和代谢物,如Faecalibacterium和D-phenyllactic acid之间的相关性.
结论:
- AR与肠道失调和代谢功能障碍有关.
- 微生物衍生代谢物通过肠鼻轴在免疫调节中发挥作用.
- 这些发现支持针对微生物群的治疗策略,用于管理AR.
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