维生素D缺乏和随后阻塞性睡眠呼吸暂停的风险:一个多机构的回顾性研究
Kuo-Chuan Hung1,2, Ting-Sian Yu3, Yi-Chen Lai1,2
1Department of Anesthesiology, Chi Mei Medical Center, Tainan, Taiwan.
Frontiers in nutrition
|November 28, 2025
概括
持续的维生素D缺乏 (VDD) 显著增加了发展阻塞性睡眠呼吸暂停 (OSA) 的风险. 这种关联随着时间的推移而保持一致,并显示出剂量反应效应,特别是在女性和年轻的超重人群中.
科学领域:
- 睡眠医学 睡眠医学
- 内分泌学 在内分泌学.
- 公共卫生 公共卫生
背景情况:
- 阻塞性睡眠呼吸暂停 (OSA) 是一个广泛的健康问题,与心血管和代谢问题有关.
- 维生素D缺乏 (VDD) 很普遍,可能在OSA发育中起作用,但证据主要是横截面的.
- 这项研究旨在确定持续的VDD是否会增加发生性OSA的风险.
研究的目的:
- 调查持续维生素D缺乏与发展阻塞性睡眠呼吸暂停的风险之间的联系.
- 探索这个协会中的时间一致性和剂量反应关系.
- 确定潜在风险较高的子组.
主要方法:
- 使用TriNetX研究网络 (2010-2023) 进行的一项回顾性队列研究包括18岁以上的成年人.
- 患者根据持续的血清25-基维生素D水平 (缺乏≤20 ng/mL,充足度≥30 ng/mL) 进行分类.
- 使用1:1的倾向得分匹配,随后对新发病的OSA诊断进行长达5年的随访,并有3个月的淘汰期.
主要成果:
- 与对照组相比,OSA风险在VDD组 (5.7%) 显著更高 (4.4%),危险比率 (HR) 为1.26.
- 观察到一种剂量反应关系,严重的VDD (≤10 ng/mL) 显示出更大的风险 (HR 1.39).
- 在女性 (HR 1.32),年轻人 (HR 1.45) 和超重/肥胖个体 (HR 1.27) 中发现了更强的关联.
结论:
- 持续的维生素D缺乏独立地与阻塞性睡眠呼吸暂停的风险增加有关.
- 时间一致性和剂量反应发现支持潜在的因果关系.
- 有针对性的干预措施可能对高风险小组有益,包括妇女,年轻人以及超重或肥胖的人.
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