动脉样硬化指数和BMI:在缺血病幸存者的认知功能新的预测指标
Lingyan Zhao1,2, Chenyang Qin1,2, Hanbo Yu1,2
1First Teaching Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin, China.
Frontiers in nutrition
|November 28, 2025
概括
较高的血动脉生成指数 (AIP) 和AIP-BMI与缺血性中风患者的认知功能恶化有关. 这些发现突出了潜在的代谢对中风后认知衰退的贡献.
科学领域:
- 心血管研究研究心血管研究
- 神经学 神经学
- 代谢综合征是代谢综合征的一种.
背景情况:
- 血动脉质指数 (AIP) 是一种已知的胰岛素耐药性标志物,与中风风险和结果有关.
- 在缺血性中风患者中AIP,AIP-BMI和认知功能之间的关系尚不清楚.
研究的目的:
- 研究血动脉质指数 (AIP) 和复合的AIP-体质指数 (AIP-BMI) 与被诊断为缺血性中风的患者的认知功能之间的关联.
- 确定较高的AIP和AIP-BMI水平是否与中风后认知表现较差相关.
主要方法:
- 一项涉及2933名缺血性中风患者的横截面研究.
- 使用日志[甘油三 (mmol/L) /高血糖-C (mmol/L) ]计算AIP,并通过迷你精神状态检查 (MMSE) 评估认知功能.
- 采用多变量线性回归模型来分析AIP (和AIP-BMI) 和MMSE得分之间的关联,并对混因素进行调整.
主要成果:
- 每增加AIP的1个单位,MMSE得分下降1.15个点 (p < 0.001).
- 在AIP-BMI中每增加1个单位对应于MMSE得分下降0.04个点 (p < 0.001).
- 这些反向关联在AIP和AIP-BMI的第三者之间是一致的.
结论:
- 升高的AIP和AIP-BMI独立地与缺血性中风患者的认知功能下降有关.
- 与失脂血症相关的代谢障碍可能在中风后的认知障碍的发展中发挥作用.
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