美国儿童的腺病毒类型 住院或在急诊室见到患有急性呼吸道疾病的儿童,2016-2019年
Tess Stopczynski1, Varvara Probst2, Adam Gailani2
1Department of Biostatistics, Vanderbilt University Medical Center, Nashville, Tennessee, USA.
Open forum infectious diseases
|November 28, 2025
概括
人类腺病毒 (HAdV) 导致儿科急性呼吸道疾病 (ARI). HAdV-B7感染与儿童更严重的结局有关,这凸显了针对性干预的类型特定分析的重要性.
科学领域:
- 病毒学 病毒学
- 儿童传染病 儿童传染病
- 公共卫生 公共卫生
背景情况:
- 人类腺病毒 (HAdV) 是全球儿科急性呼吸道疾病 (ARI) 的重要原因.
- 哈德病毒感染的临床表现因物种和类型而异.
- 了解特定类型的疾病模式对于开发有针对性的干预措施至关重要.
研究的目的:
- 描述导致儿科ARI的人类腺病毒 (HAdV) 类型.
- 调查特定HAdV类型与疾病严重程度之间的关联.
- 为了确定ARI儿童的类型特定的临床表现和结果.
主要方法:
- 一项多中心前性研究招募了7家美国儿童医院的儿童 (<18岁) 患有ARI.
- 呼吸器样本进行了HAdV测试,阳性样本进行了六合基因测序以进行类型化.
- 用通用线性混合效应模型来比较HAdV类型并评估疾病严重程度.
主要成果:
- 在1843个HAdV阳性病例中,有1402个 (76%) 是类型化的,其中HAdV-C1,HAdV-C2和HAdV-B3是最常见的.
- 感染HAdV-B7的儿童出现严重结局的几率明显更高 (aOR = 2.05).
- 症状呈现因HAdV类型而异,B种病例表现出更多非呼吸系统症状.
结论:
- 儿童的HAdV-B7感染与严重结局的风险增加有关.
- 在不同HAdV类型的临床表现和严重程度上存在显著的异质性.
- HAdV类型是未来儿童ARI预防和治疗策略的一个重要因素.
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